Review
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 14, 2019; 25(22): 2706-2719
Published online Jun 14, 2019. doi: 10.3748/wjg.v25.i22.2706
Proton pump inhibitors and dysbiosis: Current knowledge and aspects to be clarified
Giovanni Bruno, Piera Zaccari, Giulia Rocco, Giulia Scalese, Cristina Panetta, Barbara Porowska, Stefano Pontone, Carola Severi
Giovanni Bruno, Piera Zaccari, Giulia Rocco, Giulia Scalese, Carola Severi, Department of Internal Medicine and Medical Specialties, Gastroenterology Unit, Sapienza University of Rome, Rome 00161, Italy
Cristina Panetta, Stefano Pontone, Department of Surgical Sciences, Sapienza University of Rome, Rome 00161, Italy
Barbara Porowska, Department of Cardio-Thoracic, Vascular Surgery and Transplants, Sapienza University of Rome, Rome 00161, Italy
Author contributions: Bruno G, Zaccari P and Rocco G performed the literature search and wrote the manuscript; Porowska B critically revised the manuscript; Scalese G and Panetta C designed and created the figures; Pontone S and Severi C provided scientific guidance and equally contributed to the manuscript as senior authors; all authors revised and approved the final version of this article.
Conflict-of-interest statement: No potential conflicts of interest to report.
Open-Access: This article is an open-access article which was selected byan in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Stefano Pontone, MD, PhD, Research Assistant Professor, Department of Surgical Sciences, Sapienza University of Rome, V.le Regina Elena 324, Rome 00161, Italy. stefano.pontone@uniroma1.it
Telephone: +39-06-49975503
Received: March 12, 2019
Peer-review started: March 13, 2019
First decision: March 27, 2019
Revised: April 2, 2019
Accepted: April 19, 2019
Article in press: April 20, 2019
Published online: June 14, 2019
Processing time: 94 Days and 15.5 Hours
Core Tip

Core tip: The gut microbiota plays a fundamental role in the maintenance of human health. However, several drugs, including proton pump inhibitors, can cause dysbiosis, which in turn is responsible for different extra-intestinal and intestinal diseases. An up-to-date review of the literature was conducted to identify changes in gut microbiota composition related to chronic proton pump inhibitor therapy and to highlight the possible pathogenic involvement of dysbiosis in gastrointestinal disorders.