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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 28, 2019; 25(20): 2463-2472
Published online May 28, 2019. doi: 10.3748/wjg.v25.i20.2463
Published online May 28, 2019. doi: 10.3748/wjg.v25.i20.2463
Brucea javanica oil emulsion improves the effect of radiotherapy on esophageal cancer cells by inhibiting cyclin D1-CDK4/6 axis
Zhong-Hua Qiu, Wei-Wei Zhang, Gui-Hua Jiao, Department of Interventional Therapy, Affiliated Hospital of Jining Medical University, Jining, 272000, Shandong Province, China
Hong-Hua Zhang, Department of Neurology, Liangshan County People's Hospital, Jining, 272600, Shandong Province, China
Author contributions: Qiu ZH and Jiao GH designed the research; Qiu ZH and Zhang WW performed the research; Zhang HH analyzed the data; Qiu ZH wrote the paper.
Institutional review board statement: This study was reviewed and approved by the Institutional Review Board of Affiliated Hospital of Jining Medical University.
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Gui-Hua Jiao, MSc, Chief Nurse, Department of Interventional Therapy, Affiliated Hospital of Jining Medical University, Jining 272000, Shandong Province, China. zhqiu123@163.com
Telephone: +86-18853715571 Fax: +86-537-2903918
Received: March 23, 2019
Peer-review started: March 25, 2019
First decision: April 8, 2019
Revised: April 12, 2019
Accepted: May 8, 2019
Article in press: May 8, 2019
Published online: May 28, 2019
Processing time: 66 Days and 23.9 Hours
Peer-review started: March 25, 2019
First decision: April 8, 2019
Revised: April 12, 2019
Accepted: May 8, 2019
Article in press: May 8, 2019
Published online: May 28, 2019
Processing time: 66 Days and 23.9 Hours
Core Tip
Core tip:Brucea javanica oil emulsion (BJOE) is a widely used drug against various cancers. However, its anti-cancer effect and potential as a radiosensitizer have not been explored in esophageal cancer. In this study, BJOE reliably inhibited growth, migration, and invasion of esophageal cancerous cells. It was demonstrated that BJOE could be used as a radiosensitizer to promote the apoptosis in esophageal cancerous cells via the cyclin D1-cyclin-dependent kinase 4/6 axis.