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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 14, 2019; 25(18): 2204-2216
Published online May 14, 2019. doi: 10.3748/wjg.v25.i18.2204
Published online May 14, 2019. doi: 10.3748/wjg.v25.i18.2204
Characteristics of mucosa-associated gut microbiota during treatment in Crohn’s disease
Cong He, Huan Wang, Wang-Di Liao, Chao Peng, Xu Shu, Xuan Zhu, Zhen-Hua Zhu, Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China
Author contributions: He C, Wang H and Liao WD contributed to equally to this work; He C and Zhu ZH designed the research; Wang H, Liao WD, Peng C, Shu X and Zhu X enrolled the qualified patients and collected the mucosal samples; Wang H analyzed the information of the patients during treatment; He C performed the bioinformatic analysis and wrote the paper; all authors have read and approved the final version to be published.
Supported by: the National Natural Science Foundation of China , No. 81660101 and No. 81860106 ; the Special Scientific Research Fund of Public Welfare Profession of National Health and Family Planning Commission , No. 201502026 ; and the Graduate Innovation Fund of Nanchang University , No. CX2017251 .
Institutional review board statement: The study was reviewed and approved by the Medical Ethics Committee of Nanfang Hospital. All routine colonic biopsy specimens from the patients were taken after informed consent and ethical permission was obtained for participation in the study.
Conflict-of-interest statement: To the best of our knowledge, no conflict of interest exists.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Zhen-Hua Zhu, PhD, Doctor, Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, 17 Yong Waizheng Street, Donghu District, Nanchang 330006, Jiangxi Province, China. zhuzhenhua19820122@163.com
Telephone: +86-791-88692705 Fax: +86-791-88623153
Received: January 6, 2019
Peer-review started: January 7, 2019
First decision: March 13, 2019
Revised: March 25, 2019
Accepted: April 10, 2019
Article in press: April 10, 2019
Published online: May 14, 2019
Processing time: 129 Days and 1.3 Hours
Peer-review started: January 7, 2019
First decision: March 13, 2019
Revised: March 25, 2019
Accepted: April 10, 2019
Article in press: April 10, 2019
Published online: May 14, 2019
Processing time: 129 Days and 1.3 Hours
Core Tip
Core tip: The dysbiosis of gut microbiome is associated with the development of Crohn’s disease (CD), although the alteration from active CD to remission after treatment is unclear. This study illustrated that the composition of mucosa-associated gut microbiota in active CD significantly changed after the induction of remission regardless of drugs used, which got close to healthy subjects. We speculate that the maintenance of gut microbiota balance may be potential therapeutic target for reducing the risk of disease relapse.