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World J Gastroenterol. May 14, 2019; 25(18): 2188-2203
Published online May 14, 2019. doi: 10.3748/wjg.v25.i18.2188
Diversity of Saccharomyces boulardii CNCM I-745 mechanisms of action against intestinal infections
Dorota Czerucka, Patrick Rampal
Dorota Czerucka, Department of Human Health, Division of Ecosystems and Immunity, Center Scientific of Monaco, Monaco MC98000, Monaco
Patrick Rampal, Center Scientific of Monaco, Monaco MC98000, Monaco
Author contributions: Czerucka D wrote the paper; Rampal P provided the input in writing the paper and revised the manuscript.
Conflict-of-interest statement: Dorota Czerucka has served as speaker, a consultant for Biocodex, and has received research funding from Biocodex SA. Patrick Rampal has served as speaker, a consultant for Biocodex.
Open-Access: This article is an open-access article which was selected by an inhouse editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution non Commercial (CC BY-NC4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is propely cited and the use is non-commercial. See: htpp//cretivecommons.org/licenses/by-nc/4.0/
Corresponding author: Dorota Czerucka, PhD, Senior Researcher, Senior Scientist, Department of Human Health, Division of Ecosystems and Immunity, Center Scientific of Monaco, 8 Quai Antoine 1er, Monaco MC98000, Monaco. dczerucka@centrescientifique.mc
Telephone: +212-377-97774435 Fax: +212-377-98988674
Received: September 29, 2018
Peer-review started: September 29, 2018
First decision: November 7, 2018
Revised: March 21, 2019
Accepted: March 29, 2019
Article in press: March 30, 2019
Published online: May 14, 2019
Processing time: 228 Days and 17.3 Hours
Core Tip

Core tip: The efficacy of lyophilized probiotic yeast Saccharomyces boulardii CNCM I-745 was clinically demonstrated with controlled studies of intestinal infections associated with antibiotics and acute diarrhea in children. This review summerizes scientific data describing the mechanism of Saccharomyces boulardii protection against infection and emphazises the diversity of potential mechanism of action that this probiotic yeast can have against pathogenic microorganisms. More recently, effects on the recovery of the intestinal microbiota as well as on the immune system have been demonstrated, thus opening up a new therapeutic potential of this yeast.