Meta-Analysis
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 7, 2019; 25(13): 1628-1639
Published online Apr 7, 2019. doi: 10.3748/wjg.v25.i13.1628
Systematic review with meta-analysis on transplantation for alcohol-related liver disease: Very low evidence of improved outcomes
Nicole T Shen, Cristina Londono, Stephanie Gold, Ashley Wu, Keith C Mages, Robert S Jr Brown
Nicole T Shen, Robert S Jr Brown, Department of Medicine, Division of Gastroenterology and Hepatology, Weill Cornell Medicine, New York, NY 10021, United States
Cristina Londono, Ashley Wu, Department of Medicine, Weill Cornell Medical College, New York, NY 10021, United States
Stephanie Gold, Department of Medicine, Division of Internal Medicine, Weill Cornell Medicine, New York, NY 10021, United States
Keith C Mages, Department of Medicine, Weill Cornell Medical College, Samuel J. Wood Library and C.V. Starr Biomedical Information Center, New York, NY 10021, United States
Author contributions: Shen NT contributed to conception and design of study, acquisition of data, analysis and interpretation of data, drafting the article, final approval; Londono C contributed to acquisition of data, drafting the article, final approval; Gold S contributed to acquisition of data, drafting the article, final approval; Wu A contributed to drafting the article, critical revision, final approval; Mages KC contributed to conception and design of study, acquisition of data, final approval; Brown RS Jr contributed to conception and design of study, analysis and interpretation of data, critical revision, final approval.
Supported by the Agency for Healthcare Research and Quality, No. T32HS 000066-24 from.
Conflict-of-interest statement: The authors deny any conflict of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Nicole T Shen, MD, MSc, Doctor, Department of Medicine, Division of Gastroenterology and Hepatology, Weill Cornell Medicine, 1305 York Avenue 4th Floor, New York, NY 10021, United States. nts9004@nyp.org
Telephone: +1-646-9628690 Fax: +1-646-9620114
Received: February 6, 2019
Peer-review started: February 6, 2019
First decision: February 21, 2019
Revised: March 7, 2019
Accepted: March 11, 2019
Article in press: March 12, 2019
Published online: April 7, 2019
Processing time: 58 Days and 23.6 Hours
Core Tip

Core tip: Our findings suggest the dearth of well-published literature on transplantation in alcohol-related liver disease (ALD) and the urgent need for rigorous standardization in studying ALD. Such standardization would enable global scale assessment on the efficacy of transplanting ALD. Standardization should include addressing the presence and treatment of alcohol use disorder, the clinical definition of ALD, reporting the spectrum of the population studied (acute, chronic, acute on chronic, hepatocellular carcinoma in the setting of ALD), data collection, and definition and detection of relapse.