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World J Gastroenterol. Apr 7, 2019; 25(13): 1560-1565
Published online Apr 7, 2019. doi: 10.3748/wjg.v25.i13.1560
Cellular therapy: A promising tool in the future of colorectal surgery
Mohammed Mohammed El-Said, Sameh Hany Emile
Mohammed Mohammed El-Said, Sameh Hany Emile, Colorectal Surgery Unit, General Surgery Department, Mansoura University Hospitals, Mansoura University, Mansoura 35516, Egypt
Author contributions: El-Said MM and Emile SH designed, wrote, and revised the manuscript.
Conflict-of-interest statement: All authors declare no conflicts-of-interest related to this article.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Sameh Hany Emile, MBChB, MD, MSc, Lecturer, Surgeon, Colorectal Surgery Unit, General Surgery Department, Mansoura University Hospitals, Mansoura University, Dakahlia Governorate, Mansoura 35516, Egypt. sameh200@hotmail.com
Telephone: +20-1006267150 Fax: +20-50-239733
Received: January 8, 2019
Peer-review started: January 8, 2019
First decision: February 13, 2019
Revised: February 28, 2019
Accepted: March 1, 2019
Article in press: March 2, 2019
Published online: April 7, 2019
Processing time: 86 Days and 5.6 Hours
Core Tip

Core tip: Cellular therapy may be the solution of challenging problems in colorectal surgery such as impaired healing leading to anastomotic leakage and metastatic colorectal cancer. Two types of cellular therapy have been recognized, the mesenchymal stem cells (MSCs) and bone marrow-mononuclear cells therapy. These cells have been shown to accelerate and promote healing of various tissue injuries in animal and human studies. In addition, experimental studies have reported that MSCs may help suppress the progression of colon cancer in rat models.