Basic Study
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 28, 2019; 25(12): 1478-1491
Published online Mar 28, 2019. doi: 10.3748/wjg.v25.i12.1478
Gut microbiota profile in healthy Indonesians
Endang Sutriswati Rahayu, Tyas Utami, Mariyatun Mariyatun, Pratama Nur Hasan, Rafli Zulfa Kamil, Ryan Haryo Setyawan, Fathyah Hanum Pamungkaningtyas, Iskandar Azmy Harahap, Devin Varian Wiryohanjoyo, Putrika Citta Pramesi, Muhammad Nur Cahyanto, I Nengah Sujaya, Mohammad Juffrie
Endang Sutriswati Rahayu, Tyas Utami, Mariyatun Mariyatun, Pratama Nur Hasan, Rafli Zulfa Kamil, Ryan Haryo Setyawan, Fathyah Hanum Pamungkaningtyas, Iskandar Azmy Harahap, Devin Varian Wiryohanjoyo, Putrika Citta Pramesi, Muhammad Nur Cahyanto, Department of Food and Agricultural Technology, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia
I Nengah Sujaya, Department of Public Health, Udayana University, Denpasar 80234, Indonesia
Mohammad Juffrie, Department of Public Health, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia
Author contributions: Rahayu ES acted as the lead investigator; Utami T supervised the field research at the Yogyakarta site; Mariyatun performed the majority of field research at both sites; Hasan PN, Kamil RZ and Setyawan RH participated equally in field research at both sites; Pamungkaningtyas FH and Harahap IA assisted with field research and performed data analysis; Wiryohanjoyo DV wrote the paper; Pramesi PC edited the paper and was responsible for journal submission; Cahyanto MN was the consultant for the research design; Sujaya IN supervised the research at the Bali site; Juffrie M consulted from both the medical and ethical view.
Supported by The Yakult Honsha, Co., Ltd.
Institutional review board statement: All subjects agreed to participate in this study after informed consent and ethical permission was obtained.
Informed consent statement: All subjects agreed to participate in this study after informed consent and ethical permission was obtained.
Institutional animal care and use committee statement: No animals were included in this study.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Endang Sutriswati Rahayu, Dr, Professor, Department of Food and Agricultural Technology, Universitas Gadjah Mada, Jalan Flora No. 1, Bulaksumur, Sleman, Yogyakarta 55281, Indonesia. endangsrahayu@ugm.ac.id
Telephone: +26-274-589797
Received: November 21, 2018
Peer-review started: November 22, 2018
First decision: December 12, 2018
Revised: January 11, 2019
Accepted: January 26, 2019
Article in press: January 26, 2019
Published online: March 28, 2019
Processing time: 127 Days and 5.6 Hours
Core Tip

Core tip: Research on gut microbiota has been growing rapidly due to their relationship with various diseases. Two factors influencing gut microbiota are age and location. Indonesia has numerous different tribes. Hence, it is expected that each tribe will have a specific gut microbiota. This research aimed to investigate the gut microbiota of Indonesians represented by Javanese and Balinese tribes. The results showed that bacterial populations were higher in younger than elderly subjects. The most common bacterial groups were Clostridium, Prevotella, Atopobium, Bifidobacterium, and Bacteroides. The level of Clostridium perfringens between the tribes was different, which might be associated with diet and lifestyle.