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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 21, 2019; 25(11): 1366-1377
Published online Mar 21, 2019. doi: 10.3748/wjg.v25.i11.1366
Published online Mar 21, 2019. doi: 10.3748/wjg.v25.i11.1366
Diffusion-weighted magnetic resonance imaging and micro-RNA in the diagnosis of hepatic fibrosis in chronic hepatitis C virus
Tarek Besheer, Hatem Elalfy, Mohamed Abd El-Maksoud, Mahmoud El-Bendary, Department of Tropical Medicine and Hepatology, Mansoura Faculty of Medicine - Mansoura University, Mansoura 35111, Egypt
Ahmed Abd El-Razek, Saher Taman, Department of Diagnostic Radiology, Mansoura Faculty of Medicine - Mansoura University, Mansoura 35111, Egypt
Khaled Zalata, Wagdy Elkashef, Department of Pathology, Mansoura Faculty of Medicine - Mansoura University, Mansoura 35111, Egypt
Hossam Zaghloul, Heba Elshahawy, Doaa Raafat, Wafaa Elemshaty, Eman Elsayed, Department of Clinical Pathology, Mansoura Faculty of Medicine - Mansoura University, Mansoura 35111, Egypt
Abdel-Hady El-Gilany, Department of Public Health and Preventive Medicine, Mansoura Faculty of Medicine - Mansoura University, Mansoura 35111, Egypt
Author contributions: Besheer T, Elalfy H, and El-Bendary M were involved in study conception and design; Abd El-Razek A and Taman S performed radiological imaging; Zaghloul H, Elshahawy H, Raafat D, Elemshaty W, and Elsayed E performed laboratory techniques; Zalata K and Elkashef W performed pathological diagnosis of the liver biopsies; El-Gilany AH and Abd El-Maksoud M acquired the data and performed analysis and interpretation of data; all authors were involved in the drafting and critical revision of the manuscript; all authors approved the final version of the manuscript.
Supported by Science and Technology Development Foundation (STDF), Project NO. 3457 (TC/4/Health/2010/hep-1.6) .
Institutional review board statement: The study protocol was reviewed and approved by the institutional ethics committee of the Mansoura Faculty of Medicine. (R.18.04.139.R1-2018/04/17).
Informed consent statement: Written informed consent was obtained from all eligible patients who were included in the study.
Conflict-of-interest statement: No conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Mahmoud El-Bendary, MD, Professor, Department of Tropical Medicine and Hepatology, Mansoura Faculty of Medicine - Mansoura University, Elgomhoria Street, Mansoura 35111, Dakahlia, Egypt. mm_elbendary@mans.edu.eg
Telephone: +20-1002592205 Fax: +20-502267016
Received: November 12, 2018
Peer-review started: November 12, 2018
First decision: December 28, 2018
Revised: January 30, 2019
Accepted: February 15, 2019
Article in press: February 15, 2019
Published online: March 21, 2019
Peer-review started: November 12, 2018
First decision: December 28, 2018
Revised: January 30, 2019
Accepted: February 15, 2019
Article in press: February 15, 2019
Published online: March 21, 2019
Core Tip
Core tip: We aimed to assess diffusion-weighted magnetic resonance imaging and micro-RNAs in diagnosis and staging of hepatic fibrosis. Patients underwent DWI of the abdomen, micro-RNA profiling, and liver biopsy. The apparent diffusion coefficient (ADC) and miR were calculated and correlated with METAVIR score. We found that ADC value was decreased from controls (F0) to patients with early fibrosis and those with late fibrosis. Combined ADC and miR-200b revealed the best result for differentiating early from late fibrosis and offer an alternative surrogate non-invasive diagnostic tool for diagnosis and staging of hepatic fibrosis in patients with chronic hepatitis C.