Published online Mar 7, 2018. doi: 10.3748/wjg.v24.i9.971
Peer-review started: January 10, 2018
First decision: January 18, 2018
Revised: February 5, 2018
Accepted: February 8, 2018
Article in press: February 8, 2018
Published online: March 7, 2018
Core tip: The management of Helicobacter pylori (H. pylori) infection is challenging, largely due to the emergence of antibiotic resistance. A greater understanding of local antibiotic resistance rates is important in determining the most appropriate treatment regimen in a given population. Furthermore, insight into the virulence of the infecting strains and the association between virulence and antibiotic resistance could potentially be an avenue to explore in the effort to improve eradication rates. This study provides and update on the prevalence of clarithromycin and fluoroquinolone resistance in Ireland and demonstrates that less virulent strains of H. pylori are predictive of primary clarithromycin resistance.