Liu RH, Wen Y, Sun HY, Liu CY, Zhang YF, Yang Y, Huang QL, Tang JJ, Huang CC, Tang LJ. Abdominal paracentesis drainage ameliorates severe acute pancreatitis in rats by regulating the polarization of peritoneal macrophages. World J Gastroenterol 2018; 24(45): 5131-5143 [PMID: 30568390 DOI: 10.3748/wjg.v24.i45.5131]
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Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Basic Study
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World J Gastroenterol. Dec 7, 2018; 24(45): 5131-5143 Published online Dec 7, 2018. doi: 10.3748/wjg.v24.i45.5131
Abdominal paracentesis drainage ameliorates severe acute pancreatitis in rats by regulating the polarization of peritoneal macrophages
Ruo-Hong Liu, Yi Wen, Hong-Yu Sun, Chun-Yu Liu, Yu-Fan Zhang, Yi Yang, Qi-Lin Huang, Jia-Jia Tang, Can-Chen Huang, Li-Jun Tang
Ruo-Hong Liu, Yi Wen, Hong-Yu Sun, Chun-Yu Liu, Yi Yang, Qi-Lin Huang, Can-Chen Huang, Li-Jun Tang, PLA Center of General Surgery and Pancreatic Injury and Repair Key Laboratory of Sichuan Province, Chengdu Military General Hospital, Chengdu 610083, Sichuan Province, China
Ruo-Hong Liu, Yi Wen, Li-Jun Tang, Third Military Medical University (Army Medical University), Chongqing 400037, China
Yu-Fan Zhang, Jiaotong Hospital Affiliated with the Sichuan Provincial People’s Hospital, Chengdu 611730, Sichuan Province, China
Jia-Jia Tang, Department of Ultrasound, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Beijing 100032, China
Author contributions: Liu RH, Wen Y and Sun HY contributed equally to this work; Liu RH and Wen Y performed the majority of the experiments; Liu CY and Huang CC contributed to the animal experiments; Yang Y and Huang QL helped with the in vitro experiments; Zhang YF and Tang JJ contributed to data collection and manuscript preparation; Liu RH and Sun HY drafted the manuscript; and Tang LJ revised and approved the manuscript.
Supported bythe National Natural Science Foundation of China, No. 81772001, No. 8177071311 and No. 81502696; the National Clinical Key Subject of China, No. 41792113; the Technology Plan Program of Sichuan Province, No. 2015SZ0229, No. 2018JY0041 and No. 18YYJC0442; and the Science and Technology Development Plan of Sichuan Province, No. 2016YJ0023.
Correspondence author to: Li-Jun Tang, MD, PhD, Chief Doctor, PLA Center for General Surgery and Pancreatic Injury and the Repair Key Laboratory of Sichuan Province, Chengdu Military General Hospital, No. 270, Tianhui Road, Rongdu Avenue, Jinniu, Chengdu 610083, Sichuan Province, China. tanglj2016@163.com
Telephone: +86-28-86570265
Received: September 27, 2018 Peer-review started: September 27, 2018 First decision: October 14, 2018 Revised: October 20, 2018 Accepted: November 9, 2018 Article in press: November 9, 2018 Published online: December 7, 2018 Processing time: 71 Days and 22.2 Hours
Core Tip
Core tip: In the present study, we provided evidence for the first time that abdominal paracentesis drainage (APD) ameliorates inflammation in rats with severe acute pancreatitis (SAP) by regulating peritoneal macrophage M2 polarization. The important findings are that: (1) by removing pancreatitis-associated ascitic fluids, APD could improve the inflammatory environment of the peritoneal cavity; (2) the improved environment in the peritoneal cavity could polarize peritoneal macrophages towards the M2 phenotype; and (3) APD could promote M2 polarization of macrophages in the pancreas of SAP model rats. These findings provide new insights into the mechanisms underlying the effectiveness of APD, which may advance the clinical use of APD to benefit patients with SAP.
