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©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 21, 2018; 24(43): 4939-4949
Published online Nov 21, 2018. doi: 10.3748/wjg.v24.i43.4939
Published online Nov 21, 2018. doi: 10.3748/wjg.v24.i43.4939
Risk of recurrence of primary sclerosing cholangitis after liver transplantation is associated with de novo inflammatory bowel disease
Lukas Bajer, Peter Macinga, Jan Brezina, Pavel Trunecka, Julius Spicak, Pavel Drastich, Department of Gastroenterology and Hepatology, Institute for Clinical and Experimental Medicine, Prague 140 21, Czech Republic
Antonij Slavcev, Matej Roder, Department of Immunogenetics, Institute for Clinical and Experimental Medicine, Prague 140 21, Czech Republic
Eva Sticova, Department of Clinical and Transplant Pathology, Institute for Clinical and Experimental Medicine, Prague 140 21, Czech Republic
Radim Janousek, Department of Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, Prague 140 21, Czech Republic
Author contributions: All mentioned authors substantially contributed to presented research; Bajer L, Slavcev A, Sticova E and Drastich P wrote the paper; Slavcev A and Roder M performed HLA typing and analysed acquired data; Bajer L, Macinga P and Brezina J gathered and analysed retrospective data; Sticova E reviewed all relevant histological findings; Janousek R reviewed all relevant radiological findings; Trunecka P, Spicak J and Drastich P designed and supervised the research; Spicak J and Drastich P revised the manuscript
Supported by the Ministry of Health of the Czech Republic , No. 15-28064A and No. 16-27477A .
Institutional review board statement: This study was approved by The Ethics Committee with multicenter competence of the Institute for Clinical and Experimental Medicine and Thomayer Hospital.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: All authors declare that there are no competing interests regarding the publication of this paper.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Lukas Bajer, MD, Department of Gastroenterology and Hepatology, Institute for Clinical and Experimental Medicine, Videnska 1958/9, Prague 140 21, Czech Republic. lukas.bajer@ikem.cz
Telephone: +420-2-61362266 Fax: +420-2-61362615
Received: August 31, 2018
Peer-review started: September 2, 2018
First decision: October 8, 2018
Revised: October 20, 2018
Accepted: November 13, 2018
Article in press: November 13, 2018
Published online: November 21, 2018
Peer-review started: September 2, 2018
First decision: October 8, 2018
Revised: October 20, 2018
Accepted: November 13, 2018
Article in press: November 13, 2018
Published online: November 21, 2018
Core Tip
Core tip: This study demonstrates that patients with de novo colitis after liver transplantation for primary sclerosing cholangitis (PSC) are significantly predisposed towards primary liver disease recurrence (rPSC). History of acute cellular rejection of the liver graft, overlapping features of autoimmune hepatitis (autoimmune hepatitis /PSC) and certain human leukocyte antigen (HLA)-DQ and HLA-DR alleles in both donors and recipients may also have an impact on rPSC development. These data based on analysis of well-defined cohort with long median follow-up suggest that thorough routine endoscopic, radiological and immunological examination (both pre- and post-transplant) is crucial for identifying high-risk patients.