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©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 14, 2018; 24(38): 4403-4411
Published online Oct 14, 2018. doi: 10.3748/wjg.v24.i38.4403
Published online Oct 14, 2018. doi: 10.3748/wjg.v24.i38.4403
Hepatitis C virus related cirrhosis decreased as indication to liver transplantation since the introduction of direct-acting antivirals: A single-center study
Alberto Ferrarese, Giacomo Germani, Martina Gambato, Francesco Paolo Russo, Marco Senzolo, Alberto Zanetto, Sarah Shalaby, Patrizia Burra, Multivisceral Transplant Unit, Department of Surgery, Oncology and Gastroenterology, Padua University Hospital, via Giustiniani 2, Padua 35128, Italy
Umberto Cillo, Giacomo Zanus, Hepatobiliary Surgery and Liver Transplant Unit, Department of Surgery, Oncology and Gastroenterology, Padua University Hospital, via Giustiniani 2, Padua 35128, Italy
Paolo Angeli, Internal Medicine, Department of Medicine, Padua University Hospital, via Giustiniani 2, Padua 35128, Italy
Author contributions: Ferrarese A, Germani G and Burra P participated in research design, in the performance of the research and in data analysis. Russo FP, Gambato M, Zanetto A, Shalaby S, Senzolo M, Cillo U, Zanus G and Angeli P participated in research design. All Authors approved the final manuscript.
Institutional review board statement: The study protocol was approved by all members of the Local Ethical Committee “Comitato Etico per la Sperimentazione Clinica della Provincia di Padova” (protocol n. 4466/AO/18; code AOP1405).
Informed consent statement: Informed consent protocol was approved by the Local Ethical Committee. Informed consent was collected and signed by all patients included in the study.
Conflict-of-interest statement: All the Authors declare no conflict of interest regarding this paper.
Data sharing statement: Individual de-identified participant data have been anonymously collected.
STROBE statement: The manuscript has been prepared according to the STROBE statement.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Patrizia Burra, MD, PhD, Professor, Multivisceral Transplant Unit, Department of Surgery, Oncology and Gastroenterology, Padua University Hospital, via Giustiniani 2, Padova 35128, Italy. burra@unipd.it
Telephone: +39-49-8212892 Fax: +39-49-8218727
Received: June 7, 2018
Peer-review started: June 7, 2018
First decision: July 11, 2018
Revised: July 26, 2018
Accepted: August 1, 2018
Article in press: August 1, 2018
Published online: October 14, 2018
Processing time: 127 Days and 14 Hours
Peer-review started: June 7, 2018
First decision: July 11, 2018
Revised: July 26, 2018
Accepted: August 1, 2018
Article in press: August 1, 2018
Published online: October 14, 2018
Processing time: 127 Days and 14 Hours
Core Tip
Core tip: All-oral direct-acting antivirals significantly modify the natural history of hepatitis C virus (HCV) infection. According to our study, liver transplantation for HCV decompensated cirrhosis will decrease in the next future.