Copyright
©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 21, 2018; 24(35): 4061-4068
Published online Sep 21, 2018. doi: 10.3748/wjg.v24.i35.4061
Published online Sep 21, 2018. doi: 10.3748/wjg.v24.i35.4061
Serum anti-Helicobacter pylori antibody titer and its association with gastric nodularity, atrophy, and age: A cross-sectional study
Osamu Toyoshima, Toshihiro Nishizawa, Kosuke Sakitani, Tadahiro Yamakawa, Yoshiyuki Takahashi, Gastroenterology, Toyoshima Endoscopy Clinic, Tokyo 157-0066, Japan
Nobutake Yamamichi, Kazuhiko Koike, Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan
Keisuke Hata, Department of Surgical Oncology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan
Yasuyuki Seto, Department of Gastrointestinal Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan
Hidenobu Watanabe, Pathology and Cytology Laboratory Japan, Tokyo 166-0003, Japan
Hidekazu Suzuki, Medical Education Center, Keio University School of Medicine, Tokyo 160-8582, Japan
Author contributions: All authors were involved in designing the study; Toyoshima O, Nishizawa T, Sakitani K, and Suzuki H prepared the manuscript; Toyoshima O was involved with statistical analysis.
Institutional review board statement: This retrospective study was approved by the Ethical Review Committee of Hattori Clinic on September 7, 2017.
Informed consent statement: Written informed consent was obtained from all participants.
Conflict-of-interest statement: During the last five years, Yamamichi N received funds for the research from Denka Seiken Co., Ltd.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Osamu Toyoshima, MD, Director, Gastroenterology, Toyoshima Endoscopy Clinic, 6-17-5 Seijo, Setagaya-ku, Tokyo 157-0066, Japan. t@ichou.com
Telephone: +81-3-54299555 Fax: +81-3-54299511
Received: July 17, 2018
Peer-review started: July 17, 2018
First decision: July 31, 2018
Revised: August 2, 2018
Accepted: August 24, 2018
Article in press: August 24, 2018
Published online: September 21, 2018
Processing time: 65 Days and 11.3 Hours
Peer-review started: July 17, 2018
First decision: July 31, 2018
Revised: August 2, 2018
Accepted: August 24, 2018
Article in press: August 24, 2018
Published online: September 21, 2018
Processing time: 65 Days and 11.3 Hours
Core Tip
Core tip: A positive-low serum anti-Helicobacter pylori (H. pylori) antibody titer (E-plate Eiken) (10-49.9 U/mL) and a negative-high titer (3-9.9 U/mL) are associated with intestinal-type gastric cancer. A positive-high titer (≥ 50 U/mL) correlates with diffuse-type gastric cancer. Few studies have reported on the relationship between the serum antibody titer and endoscopic findings. In H. pylori-infected patients, a high titer of serum antibody was associated with gastric nodularity and atrophy. In H. pylori-infected patients, the antibody titer decreased in patients aged 60 years. Intestinal metaplasia and gastric atrophy were related to age ≥ 60 years in patients with positive titers.