Review
Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 28, 2018; 24(32): 3583-3616
Published online Aug 28, 2018. doi: 10.3748/wjg.v24.i32.3583
Prognostic significance of tumor immune microenvironment and immunotherapy: Novel insights and future perspectives in gastric cancer
Daniela Cornelia Lazăr, Mihaela Flavia Avram, Ioan Romoșan, Mărioara Cornianu, Sorina Tăban, Adrian Goldiș
Daniela Cornelia Lazăr, Ioan Romoșan, Department of Internal Medicine I, University Medical Clinic, University of Medicine and Pharmacy “Victor Babeş”, Timişoara 300041, Timiş County, Romania
Mihaela Flavia Avram, Department of Surgery X, 1st Surgery Clinic, University of Medicine and Pharmacy “Victor Babeş”, Timişoara 300041, Timiş County, Romania
Mărioara Cornianu, Sorina Tăban, Department of Pathology, University of Medicine and Pharmacy “Victor Babeş”, Timişoara 300041, Timiş County, Romania
Adrian Goldiș, Department of Gastroenterology and Hepatology, University of Medicine and Pharmacy “Victor Babeş”, Timişoara 300041, Timiş County, Romania
Author contributions: All the authors contributed equally to this work.
Conflict-of-interest statement: The authors have no conflict of interest to report.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Daniela Cornelia Lazăr, MD, PhD, Lecturer, Department of Internal Medicine I, University of Medicine and Pharmacy “Victor Babeş”, Piata Eftimie Murgu No.2, Timişoara 300041, Timiş County, Romania. lazar.daniela@umft.ro
Telephone: +4-256-220484 Fax: +4-256-220484
Received: May 5, 2018
Peer-review started: May 7, 2018
First decision: May 17, 2018
Revised: June 5, 2018
Accepted: June 27, 2018
Article in press: June 27, 2018
Published online: August 28, 2018
Processing time: 113 Days and 13 Hours
Core Tip

Core tip: The use of modern immunotherapy, including adoptive cell therapy, vaccines, and especially immune therapy using checkpoint inhibitors, has led to encouraging results in clinical trials including gastric cancer patients. This review analyzes the relationship between immune microenvironment profile of the host and tumor development, identification of the immune prognostic markers and future perspectives of immunotherapeutic strategies. The treatment algorithm should be adapted to the specific molecular profile of the gastric cancer subtype in order to obtain maximum clinical benefits.