Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 21, 2018; 24(31): 3521-3530
Published online Aug 21, 2018. doi: 10.3748/wjg.v24.i31.3521
Ubiquitin-proteasome system and oxidative stress in liver transplantation
Norma Alva, Arnau Panisello-Roselló, Marta Flores, Joan Roselló-Catafau, Teresa Carbonell
Norma Alva, Marta Flores, Teresa Carbonell, Department of Cell Biology, Physiology and Immunology, University of Barcelona, Barcelona 08028, Spain
Arnau Panisello-Roselló, Joan Roselló-Catafau, Experimental Pathology Department, Institute of Biomedical Research of Barcelona, Barcelona 08036, Spain
Author contributions: All authors contribute equally to the writing of the manuscript and approved the final version.
Supported by Fondo de Investigaciones Sanitarias, Ministerio de Economia y Competitividad (Madrid, Spain), No. PI15/00110.
Conflict-of-interest statement: The authors have no conflict of interest to declare.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Teresa Carbonell, PhD, Associate Professor, Research Scientist, Department of Cell Biology, Physiology and Immunology, University of Barcelona, Avda Diagonal, 643, Barcelona 08028, Catalonia, Spain.
Telephone: +34-93-4035924
Received: May 5, 2018
Peer-review started: May 5, 2018
First decision: May 17, 2018
Revised: June 28, 2018
Accepted: June 30, 2018
Article in press: June 30, 2018
Published online: August 21, 2018
Core Tip

Core tip: Ischemia-reperfusion injury is a complex multifactorial process that causes cell damage during liver transplantation. The role of the ubiquitin proteasome system during liver transplantation remains unclear. The use of proteasome inhibitors is a new strategy aimed at improving organ preservation.