Copyright
©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 21, 2018; 24(31): 3513-3520
Published online Aug 21, 2018. doi: 10.3748/wjg.v24.i31.3513
Published online Aug 21, 2018. doi: 10.3748/wjg.v24.i31.3513
Osteoporosis in primary biliary cholangitis
Christopher J Danford, Hirsh D Trivedi, Konstantinos Papamichael, Alan Bonder, Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, Unites States
Elliot B Tapper, Department of Hepatology, University of Michigan, Ann Arbor, MI 48109, Unites States
Author contributions: Danford CJ and Trivedi HD performed the literature search and drafting of the manuscript; all authors participated in the conceptual design of the paper and revision of the manuscript.
Supported by NIH T32 training grant , No. 4T32GM103702-04 to Trivedi HD .
Conflict-of-interest statement: There are no other financial disclosures or conflicts of interest in the production of this manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Alan Bonder, MD, Attending Doctor, Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, 110 Francis St. Suite 8E, Boston, MA 02215, United States. abonder@bidmc.harvard.edu
Telephone: +1-617-6321070 Fax: +1-617-6231065
Received: June 1, 2018
Peer-review started: June 1, 2018
First decision: July 6, 2018
Revised: July 11, 2018
Accepted: July 22, 2018
Article in press: July 22, 2018
Published online: August 21, 2018
Peer-review started: June 1, 2018
First decision: July 6, 2018
Revised: July 11, 2018
Accepted: July 22, 2018
Article in press: July 22, 2018
Published online: August 21, 2018
Core Tip
Core tip: This article reviews the available literature on the pathophysiology and management of osteoporosis in primary biliary cholangitis (PBC). PBC-related osteoporosis is driven mainly by decreased bone formation as opposed to the increased bone resorption seen in postmenopausal osteoporosis. Despite this and a lack of evidence of efficacy, bisphosphonates remain the cornerstone of treatment. Future attention should be given to the use of anabolic bone agents in the treatment of PBC-related osteoporosis.