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World J Gastroenterol. Jul 28, 2018; 24(28): 3101-3111
Published online Jul 28, 2018. doi: 10.3748/wjg.v24.i28.3101
Encapsulating peritoneal sclerosis
Christopher J Danford, Steven C Lin, Martin P Smith, Jacqueline L Wolf
Christopher J Danford, Steven C Lin, Jacqueline L Wolf, Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, United States
Martin P Smith, Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, United States
Author contributions: Danford CJ and Lin SC contributed equally in performing the literature search, review, and drafting of the manuscript, and they should be as co-first authors; Danford CJ, Lin SC, Smith MP and Wolf JL participated in the critical review, revision of the manuscript, and approve of the final draft of the manuscript.
Conflict-of-interest statement: There are no financial disclosures or conflicts of interest in the production of this manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Jacqueline L Wolf, MD, Associate Professor, Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Rabb 433, Boston, MA 02115, United States. jwolf1@bidmc.harvard.edu
Telephone: +1-617-6671676 Fax: +1-617-6675826
Received: May 16, 2018
Peer-review started: May 17, 2018
First decision: May 30, 2018
Revised: June 7, 2018
Accepted: June 25, 2018
Article in press: June 25, 2018
Published online: July 28, 2018
Processing time: 71 Days and 7.4 Hours
Core Tip

Core tip: Encapsulating peritoneal sclerosis (EPS) is a rare, but potentially devastating disorder. Most literature is derived from the nephrology literature surrounding peritoneal dialysis, however, the gastroenterologist is likely to encounter EPS from a variety of etiologies. We present a comprehensive review of EPS from all etiologies and a summary of treatments from a gastroenterologist’s perspective including the role of nutrition, surgery, immunosuppression, anti-fibrotic agents, and the novel use of μ-opioid antagonists and guanylate cyclase C agonists in the management of patients with EPS.