Sýkora J, Pomahačová R, Kreslová M, Cvalínová D, Štych P, Schwarz J. Current global trends in the incidence of pediatric-onset inflammatory bowel disease. World J Gastroenterol 2018; 24(25): 2741-2763 [PMID: 29991879 DOI: 10.3748/wjg.v24.i25.2741]
Corresponding Author of This Article
Jan Schwarz, MD, Assistant Professor, Division of Gastroenterology, Hepatology and Nutrition, Department of Paediatrics, Charles University in Prague, Faculty of Medicine in Pilsen, Faculty Hospital, Alej Svobody 80, Pilsen 304 60, Czech Republic. schwarzj@fnplzen.cz
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Systematic Reviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Jul 7, 2018; 24(25): 2741-2763 Published online Jul 7, 2018. doi: 10.3748/wjg.v24.i25.2741
Current global trends in the incidence of pediatric-onset inflammatory bowel disease
Josef Sýkora, Renáta Pomahačová, Marcela Kreslová, Dominika Cvalínová, Přemysl Štych, Jan Schwarz
Josef Sýkora, Renáta Pomahačová, Marcela Kreslová, Dominika Cvalínová, Jan Schwarz, Division of Gastroenterology, Hepatology and Nutrition, Department of Paediatrics, Charles University in Prague, Faculty of Medicine in Pilsen, Faculty Hospital, Pilsen 304 60, Czech Republic
Přemysl Štych, Department of Applied Geoinformatics and Cartography, Charles University in Prague, Faculty of Science, Prague 128 43, Czech Republic
Author contributions: Sýkora J and Schwarz J contributed equally to this work, and were responsible for the conception, the study design, the integrity of the data and the accuracy of the data analysis and performed the data acquisition; Pomahačová R, Kreslová M, Cvalínová D and Štych P analyzed the data, drafted the manuscript and revised it critically for important intelectuall content; Štych P performed and edited choropleth maps; Sýkora J and Schwarz J wrote the manuscript; all authors have seen and approved the version of manuscript to be submitted.
Supported bythe “On Our Own Feet Movement - Přátelé stonožky” - Endowment Program; and Research Project Progress Q-39.
Conflict-of-interest statement: The authors have no conflicts of interest to disclose.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Jan Schwarz, MD, Assistant Professor, Division of Gastroenterology, Hepatology and Nutrition, Department of Paediatrics, Charles University in Prague, Faculty of Medicine in Pilsen, Faculty Hospital, Alej Svobody 80, Pilsen 304 60, Czech Republic. schwarzj@fnplzen.cz
Telephone: +420-377-104330 Fax: +420-377-104693
Received: March 29, 2018 Peer-review started: March 29, 2018 First decision: May 9, 2018 Revised: June 1, 2018 Accepted: June 25, 2018 Article in press: June 25, 2018 Published online: July 7, 2018 Processing time: 97 Days and 13 Hours
Core Tip
Core tip: The incidence of inflammatory bowel disease (IBD) is unclear in the pediatric literature. We comprehensively reviewed and critically evaluated population-based and national cohort studies investigating the incidence of IBD and its global trends. One hundred forty studies met the inclusion criteria. The incidence of pediatric-onset IBD has been steadily increasing over time in different geographical areas in both developed and developing regions worldwide, whereas those in the West may have reached a plateau. This indicates the emergence of an IBD epidemic; however, incidence data from developing regions are limited. Exploring the changes and increasing incidence of pediatric IBD may provide new insights into the potential etiology of IBD.
