Basic Study
Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 7, 2018; 24(21): 2269-2278
Published online Jun 7, 2018. doi: 10.3748/wjg.v24.i21.2269
Multiple cytokine profiling in serum for early detection of gastric cancer
Jian Li, Liang Xu, Zeng-Ci Run, Wen Feng, Wen Liu, Peng-Jun Zhang, Zhi Li
Jian Li, Zeng-Ci Run, Zhi Li, Department of General Surgery, Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou 450000, Henan Province, China
Liang Xu, Department of Oncology, General Hospital of Liaohe Oil Field, Panjin 124010, Liaoning Province, China
Wen Feng, Department of Pathology, Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou 450000, Henan Province, China
Wen Liu, Department of Central Laboratory, Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou 450000, Henan Province, China
Peng-Jun Zhang, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Interventional Therapy Department, Peking University Cancer Hospital & Institute, Beijing 100142, China
Author contributions: Li J, Zhang PJ and Li Z designed the study; Li J, Xu L, Feng W and Liu W performed the research; Li J, Xu L, Run ZC, Feng W and Liu W analyzed the data; Li J wrote the paper; Li J and Li Z revised the manuscript for final submission; Li J and Xu L contributed equally to this study.
Supported by Henan Province Science and Technology Research Projects, No. 162102310041; National Key R&D Program of China, No. 2016YFC0106604; and National Natural Science Foundation of China, No. 81502591.
Institutional review board statement: The study was reviewed and approved by the Affiliated Tumor Hospital of Zhengzhou University Institutional Review Board.
Informed consent statement: All study participants or their legal guardian provided written informed consent prior to study enrollment.
Conflict-of-interest statement: We declare that we have no financial or personal relationships with other individuals or organizations that can inappropriately influence our work and that there is no professional or other personal interest of any nature in any product, service and/or company that could be construed as influencing the position presented in or the review of the manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Zhi Li, MD, Chief Doctor, Department of General Surgery, Affiliated Tumor Hospital of Zhengzhou University, 127 Dong Ming Road, Jin Shui District, Zhengzhou 450000, Henan Province, China. lizhihn2009@163.com
Telephone: +86-371-65588142 Fax: +86-371-65588142
Received: February 12, 2018
Peer-review started: February 12, 2018
First decision: February 23, 2018
Revised: February 27, 2018
Accepted: March 18, 2018
Article in press: March 18, 2018
Published online: June 7, 2018
Processing time: 111 Days and 23.4 Hours
Core Tip

Core tip: We aimed to use multiparameter joint analysis for improving sensitivity and specificity for detection of gastric cancer. By combining CEA, CA724, IL-6, IL-8 and TNF-α, we built a diagnostic model, which may provide potential assistance as a screening method for the early detection of gastric cancer.