Minireviews
Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 14, 2018; 24(18): 1989-1994
Published online May 14, 2018. doi: 10.3748/wjg.v24.i18.1989
Mouse models for investigating the underlying mechanisms of nonalcoholic steatohepatitis-derived hepatocellular carcinoma
Kazuki Takakura, Tsunekazu Oikawa, Yoichi Tomita, Yusuke Mizuno, Masanori Nakano, Chisato Saeki, Yuichi Torisu, Masayuki Saruta
Kazuki Takakura, Tsunekazu Oikawa, Yoichi Tomita, Yusuke Mizuno, Masanori Nakano, Chisato Saeki, Yuichi Torisu, Masayuki Saruta, Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo 105-8461, Japan
Author contributions: Takakura K and Oikawa T wrote the manuscript; Tomita Y, Mizuno Y, Nakano M and Saeki C critically appraised the manuscript; Torisu Y and Saruta M formatted and edited the final manuscript.
Conflict-of-interest statement: All of the authors declare no potential conflicts of interest relevant to this article.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Kazuki Takakura, MD, PhD, Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8, Nishi-shimbashi, Minato-ku, Tokyo 105-8461, Japan. ktakakura@jikei.ac.jp
Telephone: +81-3-34331111 Fax: +81-3-34350569
Received: March 29, 2018
Peer-review started: April 4, 2018
First decision: April 27, 2018
Revised: May 1, 2018
Accepted: May 6, 2018
Article in press: May 6, 2018
Published online: May 14, 2018
Processing time: 37 Days and 7.9 Hours
Core Tip

Core tip: This review provides a brief overview of the molecular mechanisms underlying progression to hepatocellular carcinoma from nonalcoholic steatohepatitis that have been identified to date using the array of mouse models currently available and popular in the experimental field.