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©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 7, 2018; 24(17): 1901-1910
Published online May 7, 2018. doi: 10.3748/wjg.v24.i17.1901
Published online May 7, 2018. doi: 10.3748/wjg.v24.i17.1901
Mitochondrial pathway mediated by reactive oxygen species involvement in α-hederin-induced apoptosis in hepatocellular carcinoma cells
Jiao Li, Dan-Dan Wu, Ji-Xiang Zhang, Jing-Jing Ma, Xue Hu, Department of Gastroenterology, Renmin Hospital of Wuhan University, Central Laboratory of Renmin Hospital, Wuhan 430060, Hubei Province, China
Jing Wang, Department of Gastroenterology, Beijing Shijitan Hospital of Capital Medical University, Beijing 100038, China
Wei-Guo Dong, Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China
Author contributions: Li J, Wu DD, Zhang JX, Wang J and Dong WG designed the research; Li J, Wu DD and Ma JJ performed the research; Zhang JX and Wang J contributed new reagents/analytical tools; Li J, Hu X and Ma JJ analyzed the data; Li J wrote the manuscript.
Supported by the National Natural Science Foundation of China, No. 81572426; and the Natural Science Foundation of Hubei Province, No. 2015CKB755.
Institutional animal care and use committee statement: All animal experiments were performed in accordance with the recommendations in the Guide for the Care and Use of Laboratory Animals of Wuhan University.
Conflict-of-interest statement: The authors declare that there are no conflicts-of-interest regarding the publication of this paper.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The ARRIVE guidelines have been adopted.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Wei-Guo Dong, MD, PhD, Department of Gastroenterology, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan 430060, Hubei Province, China. dongweiguo@whu.edu.cn
Telephone: +86-13986167388
Received: March 1, 2018
Peer-review started: March 2, 2018
First decision: March 30, 2018
Revised: April 4, 2018
Accepted: April 9, 2018
Article in press: April 9, 2018
Published online: May 7, 2018
Processing time: 66 Days and 3 Hours
Peer-review started: March 2, 2018
First decision: March 30, 2018
Revised: April 4, 2018
Accepted: April 9, 2018
Article in press: April 9, 2018
Published online: May 7, 2018
Processing time: 66 Days and 3 Hours
Core Tip
Core tip: The α-hederin saponin induces apoptosis of hepatocellular carcinoma cells in vitro and in vivo. We found that reactive oxygen species and the mitochondrial pathway play a vital role in α-hederin-induced apoptosis.