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World J Gastroenterol. Apr 28, 2018; 24(16): 1725-1733
Published online Apr 28, 2018. doi: 10.3748/wjg.v24.i16.1725
Nucleotide-binding oligomerization domain 1 and Helicobacter pylori infection: A review
Kosuke Minaga, Tomohiro Watanabe, Ken Kamata, Naoki Asano, Masatoshi Kudo
Kosuke Minaga, Tomohiro Watanabe, Ken Kamata, Masatoshi Kudo, Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka 589-8511, Japan
Naoki Asano, Division of Gastroenterology, Tohoku University Graduate School of Medicine, Miyagi 980-8574, Japan
Author contributions: Minaga K and Watanabe T wrote the manuscript draft and prepared the figures; Kamata K, Asano N and Kudo M assisted in writing the manuscript and reviewed the final version.
Conflict-of-interest statement: None of the authors has any conflict of interests related to this manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Tomohiro Watanabe, MD, PhD, Associate Professor, Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka 589-8511, Japan. tomohiro@med.kindai.ac.jp
Telephone: +81-72-366-0221 Fax: +81-72-367-2880
Received: March 6, 2018
Peer-review started: March 6, 2018
First decision: March 29, 2018
Revised: April 3, 2018
Accepted: April 9, 2018
Article in press: April 9, 2018
Published online: April 28, 2018
Processing time: 51 Days and 19.4 Hours
Core Tip

Core tip: Nucleotide-binding oligomerization domain 1 (NOD1), an intracellular innate immune sensor, plays a role in mucosal host defense systems against Helicobacter pylori (H. pylori) infection. NOD1 activation is involved in the generation of T helper type 1 responses against H. pylori through activation of type I IFN signaling pathways. NOD1 activation prevents gastric carcinogenesis through negative regulation of caudal-related homeobox 2 expression.