Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 21, 2018; 24(15): 1591-1600
Published online Apr 21, 2018. doi: 10.3748/wjg.v24.i15.1591
Nutrition status and Helicobacter pylori infection in patients receiving hemodialysis
Mitsushige Sugimoto, Hideo Yasuda, Akira Andoh
Mitsushige Sugimoto, Division of Digestive Endoscopy, Shiga University of Medical Science Hospital, Shiga 520-2192, Japan
Hideo Yasuda, First Department of Medicine, Hamamatsu University School of Medicine, Shizuoka 431-3192, Japan
Akira Andoh, Department of Gastroenterology, Shiga University of Medical Science Hospital, Shiga 520-2192, Japan
Author contributions: Sugimoto M, Yasuda H and Andoh A wrote the paper.
Conflict-of-interest statement: No potential conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Mitsushige Sugimoto MD, PhD, Associate Professor, Division of Digestive Endoscopy, Shiga University of Medical Science Hospital, Seta Tsukinowa-cho, Shiga 520-2192, Japan.
Telephone: +81-77-5482618 Fax: +81-77-5482618
Received: February 23, 2018
Peer-review started: February 23, 2018
First decision: March 15, 2018
Revised: March 18, 2018
Accepted: March 25, 2018
Article in press: March 25, 2018
Published online: April 21, 2018
Core Tip

Core tip: Hemodialysis (HD) patients have a poor prognosis related in part to protein-energy wasting (PEW), associated with low levels of ghrelin. The severity of gastric mucosal atrophy has been suggested as the major determinant of ghrelin levels. Eradication of Helicobacter pylori (H. pylori) improves nutritional status, with serum cholinesterase and cholesterol levels stimulated by rising ghrelin levels and appetite, especially in H. pylori infection-positive patients with severe gastric mucosal atrophy. Although infection rates of H. pylori have been decreasing in HD patients, it would be preferable to eradicate H. pylori promptly before progression of gastric atrophy for prevention of gastric cancer and PEW.