Basic Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 7, 2017; 23(9): 1594-1601
Published online Mar 7, 2017. doi: 10.3748/wjg.v23.i9.1594
miR-1181 inhibits invasion and proliferation via STAT3 in pancreatic cancer
Jie Wang, Xing-Jun Guo, You-Ming Ding, Jian-Xin Jiang
Jie Wang, Department of Hepatic-Biliary-Pancreatic Surgery, The Affiliated Hospital of Guizhou Medical University, Guiyang 550000, Guizhou Province, China
Xing-Jun Guo, Department of Biliary-Pancreatic Surgery, Affiliated Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
You-Ming Ding, Jian-Xin Jiang, Department of Hepatic-Biliary-Pancreatic Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China
Author contributions: Wang J and Guo XJ contributed equally to this work; Wang J performed the majority of experiments and analyzed the data; Guo XJ performed the molecular investigations; Guo XJ, Ding YM and Jiang JX designed and coordinated the research; Wang J, Guo XJ and Jiang JX wrote the paper.
Supported by The National Natural Science Foundation of China, No. 81160311 and No. 81572429 to Jiang JX.
Institutional review board statement: The project was reviewed by the local Research and audit Department and approved without the need for the further ethical approval.
Conflict-of-interest statement: No benefits in any form have been received or will be received from a commercial party related directly or indirectly to the subject of this article.
Data sharing statement: No additional data are available
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Jian-Xin Jiang, Department of Hepatic-Biliary-Pancreatic Surgery, Renmin Hospital of Wuhan University, 99 Ziyang Road, Wuhan 430030, Hubei Province, China. jjx731003@163.com
Telephone: +86-27-88041911 Fax: +86-27-88041911
Received: July 7, 2016
Peer-review started: July 13, 2016
First decision: September 28, 2016
Revised: October 9, 2016
Accepted: February 7, 2017
Article in press: February 8, 2017
Published online: March 7, 2017
Processing time: 241 Days and 23.5 Hours
Core Tip

Core tip: We found that miR-1181 may be involved in pancreatic cancer cell invasion and proliferation by targeting signal transducer and activator of transcription 3. Our findings suggest that miR-1181 may be a potential therapeutic agent for pancreatic cancer.