Observational Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 28, 2017; 23(8): 1477-1488
Published online Feb 28, 2017. doi: 10.3748/wjg.v23.i8.1477
Different phenotypes of monocytes in patients with new-onset mild acute pancreatitis
Man-Li Zhang, Yan-Fang Jiang, Xin-Rui Wang, Li-Li Ding, Hong-Juan Wang, Qing-Qing Meng, Pu-Jun Gao
Man-Li Zhang, Qing-Qing Meng, Department of Hepatology and Gastroenterology, The Second Part of First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Man-Li Zhang, Yan-Fang Jiang, Xin-Rui Wang, Hong-Juan Wang, Department of Central Laboratory, The Second Part of First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Xin-Rui Wang, Hong-Juan Wang, Pu-Jun Gao, Department of Hepatology, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Yan-Fang Jiang, Key Laboratory of Zoonosis Research, Ministry of Education, Jilin University, Changchun 130021, Jilin Province, China
Li-Li Ding, Department of Intensive Care Unit, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Author contributions: Gao PJ designed the research; Zhang ML, Wang XR and Wang HJ performed the research; Zhang ML, Ding LL and Meng QQ analyzed the data; Zhang ML and Jiang YF wrote the paper.
Institutional review board statement: The study was reviewed and approved by the Human Ethics Committee of the First Hospital of Jilin University.
Conflict-of-interest statement: The authors declare no financial or commercial conflicts of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Pu-Jun Gao, MD, PhD, Department of Hepatology, The First Hospital of Jilin University, 71 Xinmin Street, Changchun 130021, Jilin Province, China. pujun-gao@163.com
Telephone: +86-431-84808239 Fax: +86-431-84808391
Received: September 30, 2016
Peer-review started: October 8, 2016
First decision: December 19, 2016
Revised: January 13, 2017
Accepted: January 17, 2017
Article in press: January 17, 2017
Published online: February 28, 2017
Processing time: 149 Days and 8.4 Hours
Core Tip

Core tip: This is the first study on the numbers of different phenotypes of peripheral blood monocytes in patients with new-onset mild acute pancreatitis (MAP). Increased numbers of CD14+CD163- and CD14+CD163-MAC387+ M1 monocytes were positively correlated with the levels of plasma C-reactive protein (CRP), which suggest that pro-inflammatory monocytes may participate in the pathogenesis of MAP. The increased numbers of CD14+CD163+CD115+ M2 monocytes were positively correlated with the plasma CRP levels and the acute physiology and chronic health evaluation II scores, suggesting that the numbers of CD14+CD163+CD115+ monocytes may be a valuable biomarker for evaluating the severity of MAP. Our findings may provide new insights into the pathogenic process and immunoregulation of MAP.