Basic Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 28, 2017; 23(8): 1353-1366
Published online Feb 28, 2017. doi: 10.3748/wjg.v23.i8.1353
Anti-inflammatory intestinal activity of Combretum duarteanum Cambess. in trinitrobenzene sulfonic acid colitis model
Gedson Rodrigues de Morais Lima, Flavia Danniele Frota Machado, Larissa Lucena Périco, Felipe Meira de Faria, Anderson Luiz-Ferreira, Alba Regina Monteiro Souza Brito, Cláudia Helena Pellizzon, Clélia Akiko Hiruma-Lima, Josean Fechine Tavares, José Maria Barbosa Filho, Leônia Maria Batista
Gedson Rodrigues de Morais Lima, Flavia Danniele Frota Machado, Josean Fechine Tavares, José Maria Barbosa Filho, Leônia Maria Batista, Departamento de Ciências Farmacêuticas, Centro de Ciências da Saúde, Laboratório de Farmacologia do Trato Gastrintestinal, Universidade Federal da Paraíba (UFPB), Cidade Universitária, João Pessoa, Paraíba, CEP 58051-970, Brazil
Larissa Lucena Périco, Clélia Akiko Hiruma-Lima, Departamento de Fisiologia, Instituto de Biociências, Universidade Estadual Paulista, Botucatu, São Paulo 18618-970, Brazil
Felipe Meira de Faria, Alba Regina Monteiro Souza Brito, Departamento de Biologia Estrutural e Funcional, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), Campinas, São Paulo 13083-970, Brazil
Anderson Luiz-Ferreira, Departamento de Ciencias Biológicas, Instituto de Biotecnologia, Universidade Federal de Goiás, Catalão, Goiás, 75704-020, Brazil
Cláudia Helena Pellizzon, Departamento de Morfologia, Instituto de Biociências, Universidade Estadual Paulista, Botucatu, São Paulo 18618-970, Brazil
Author contributions: de Morais Lima GR, Machado FDF, Périco LL, de Faria FM, Luiz-Ferreira A, Souza Brito ARM, Pellizzon CH, Hiruma-Lima CA, Tavares JF, Barbosa Filho JM and Batista LM contributed to the conception and design of the study, performed most of the experiments, coordinated the study, participated in writing the manuscript and approved the final version of the article to be published.
Institutional review board statement: The protocol was approved by the Committee for Ethics in Animal Experimentation, Laboratory of Pharmaceutical Technology, Federal University of Paraíba (CEPA/LTF/UFPB), João Pessoa, Paraíba, Brazil.
Institutional animal care and use committee statement: The experimental protocols were approved by the Committee for Ethics in Animal Experimentation (CEPA/LTF/UFPB) under number 1112/10.
Conflict-of-interest statement: The authors declare no conflict of interest exists.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Leônia Maria Batista, PhD, Departamento de Ciências Farmacêuticas, Centro de Ciências da Saúde, Laboratório de Farmacologia do Trato Gastrintestinal, Universidade Federal da Paraíba (UFPB), Cidade Universitária, s/n - Castelo Branco, João Pessoa, Paraíba, CEP 58051-970, Brazil. leoniab@uol.com.br
Telephone: +55-83-32167307 Fax: +55-83-32167502
Received: September 29, 2016
Peer-review started: October 1, 2016
First decision: October 20, 2016
Revised: November 8, 2016
Accepted: December 8, 2016
Article in press: December 8, 2016
Published online: February 28, 2017
Processing time: 149 Days and 19.9 Hours
Core Tip

Core tip: Inflammatory bowel diseases are chronic inflammatory disorders that include Crohn’s disease and ulcerative colitis (UC). Genetic, immunologic and environmental factors are postulated as possible etiologic agents. Their conventional treatment is centered in reducing inflammation and abnormal symptom relief. A variety of herbal medicines have been demonstrated to produce promising results in the treatment of those diseases. Combretum duarteanum is a species popularly used in folk medicine to treat inflammation. Thus, the present study was designed to evaluate the intestinal anti-inflammatory effect in an UC rat model, contributing to the safe use and collaborating with the scientific knowledge of natural products.