Basic Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 28, 2017; 23(8): 1345-1352
Published online Feb 28, 2017. doi: 10.3748/wjg.v23.i8.1345
Autoantibody profiles in autoimmune hepatitis and chronic hepatitis C identifies similarities in patients with severe disease
Kawa Amin, Aram H Rasool, Ali Hattem, Taha AM Al-Karboly, Taher E Taher, Jonas Bystrom
Kawa Amin, Department of Medical Science, Respiratory Medicine and Allergology, Clinical Chemistry and Asthma Research Centre, Uppsala University and University Hospital, SE-751 85 Uppsala, Sweden
Kawa Amin, Department of Microbiology/Immunology, School of Medicine, University of Sulaimani, Sulaimani 334, Iraq
Aram H Rasool, Laboratory Department, General Hospital of Derbandixan, Derbandixan 332, Iraq
Ali Hattem, Department of Community Health, Sulaimani Polytechnic University, Sulaimani 334, Iraq
Taha AM Al-Karboly, Department of Medicine, School of Medicine, Faculty of Medical Sciences, University of Sulaimani; Kurdistan Center for Gastroenterology and Hepatology, Sulaimani 334, Iraq
Taher E Taher, Jonas Bystrom, Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and the London, Queen Mary, University of London, Charterhouse Square, EC1M 6BQ London, United Kingdom
Author contributions: Amin K, Rasool AH, Hattem A, Al-Karboly TAM, Taher TE and Bystrom J designed the experiments for this study; Rasool AH, Hattem A and Al-Karboly TAM performed the experiments; Amin K, Rasool AH, Hattem A, Al-Karboly TAM, Taher TE and Bystrom J analysed the data and wrote the manuscript.
Supported by Bror Hjerpstedts Foundation, Sweden.
Institutional review board statement: Approval of the study was received from the Ethics board and the Office of the vice president for scientific affairs and postgraduate studies at the Sulimani University.
Conflict-of-interest statement: The authors declare no conflict to interest.
Data sharing statement: If they received a written request, for scientific purposes, the authors would be able to share the (anonymized) raw data used in this manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Kawa Amin, PhD, Assistant Professor, Department of Microbiology/Immunology, School of Medicine, University of Sulaimani, Sulaimani 334, Iraq. kawa.amin@univsul.edu.iq
Telephone: +964-7701958515
Received: September 23, 2016
Peer-review started: September 26, 2016
First decision: October 28, 2016
Revised: November 17, 2016
Accepted: December 8, 2016
Article in press: December 8, 2016
Published online: February 28, 2017
Processing time: 155 Days and 23 Hours
Core Tip

Core tip: This paper aims to determine what patients with chronic hepatitis C (CHC) and autoimmune hepatitis (AIH) produce autoantibodies. Disease duration in CHC is linked to disease severity and autoantibodies. Patients with severe CHC resemble AIH.