Retrospective Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 21, 2017; 23(7): 1224-1232
Published online Feb 21, 2017. doi: 10.3748/wjg.v23.i7.1224
Post-transplant lymphoproliferative disorder after liver transplantation: Incidence, long-term survival and impact of serum tacrolimus level
Ahad Eshraghian, Mohammad Hadi Imanieh, Seyed Mohsen Dehghani, Saman Nikeghbalian, Alireza Shamsaeefar, Frouzan Barshans, Kourosh Kazemi, Bita Geramizadeh, Seyed Ali Malek-Hosseini
Ahad Eshraghian, Mohammad Hadi Imanieh, Seyed Mohsen Dehghani, Saman Nikeghbalian, Alireza Shamsaeefar, Kourosh Kazemi, Bita Geramizadeh, Seyed Ali Malek-Hosseini, Transplant Research Center, Shiraz University of Medical Sciences, Shiraz 71937-11351, Iran
Ahad Eshraghian, Mohammad Hadi Imanieh, Seyed Mohsen Dehghani, Frouzan Barshans, Gastroenterohepatology Research Center, Namazi Hospital, Shiraz 71937-11351, Iran
Author contributions: Eshraghian A and Imanieh MH contributed to the study concept and design; Eshraghian A, Imanieh MH and Barshans F drafted of the manuscript; Eshraghian A, Imanieh MH, Dehghani SM, Nikeghbalian S, Barshans F, Kazemi K and Malek-Hosseini SA contributed to acquisition, analysis and interpretation of data; Eshraghian A, Imanieh MH, Dehghani SM, Nikeghbalian S, Kazemi K and Malek-Hosseini SA also contributed to the patient care; Eshraghian A, Imanieh MH, Dehghani SM, Nikeghbalian S, Kazemi K, Geramizadeh B and Malek-Hosseini SA critically revised the manuscript for important intellectual content; and Geramizadeh B also contributed to the pathology review, acquisition of data; all the authors contributed to this manuscript.
Conflict-of-interest statement: The authors have no conflict of interest. The study was supported by a grant from Shiraz University of Medical Sciences.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Ahad Eshraghian, MD, Gastroenterohepatology Research Center, Namazi Hospital, Fars Province, Shiraz, District 1, Shiraz 71937-11351, Iran. eshraghiana@yahoo.com
Telephone: +98-71-36281442 Fax: +98-71-36281442
Received: September 19, 2016
Peer-review started: September 19, 2016
First decision: October 28, 2016
Revised: December 3, 2016
Accepted: January 18, 2017
Article in press: January 18, 2017
Published online: February 21, 2017
Processing time: 154 Days and 16.9 Hours
Core Tip

Core tip: Post-transplant lymphoproliferative disorder (PTLD) is one of the complications that may occur after liver transplantation. The present study is a survival analysis of liver transplant patients after PTLD development. The incidence of PTLD was 6.25% in pediatric patients and 1.18% in adult liver transplant recipients. The main new finding is association of serum tacrolimus level with post-PTLD survival. Higher serum tacrolimus level was associated with lower post-PTLD survival in pediatric patients.