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World J Gastroenterol. Dec 28, 2017; 23(48): 8443-8451
Published online Dec 28, 2017. doi: 10.3748/wjg.v23.i48.8443
Mechanisms of autophagy activation in endothelial cell and their targeting during normothermic machine liver perfusion
Yuri L Boteon, Richard Laing, Hynek Mergental, Gary M Reynolds, Darius F Mirza, Simon C Afford, Ricky H Bhogal
Yuri L Boteon, Richard Laing, Hynek Mergental, Darius F Mirza, Ricky H Bhogal, The Liver Unit, University Hospitals of Birmingham, Mindelsohn Way, Edgbaston, Birmingham B15 2TT, United Kingdom
Yuri L Boteon, Richard Laing, Hynek Mergental, Gary M Reynolds, Darius F Mirza, Simon C Afford, Ricky H Bhogal, The Centre for Liver Research, Centre for Liver Research, National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre, Institute for Biomedical Research, University of Birmingham, Birmingham B15 2TT, United Kingdom
Author contributions: Boteon YL and Bhogal RH wrote the manuscript; Mergental H, Mirza DF and Afford SC critically appraised the manuscript; Reynolds GM performed the immunohistochemistry; Bhogal RH formatted and edited the final manuscript.
Conflict-of-interest statement: No potential conflicts of interest relevant to this article were reported.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Ricky H Bhogal, the Centre for Liver Research, Institute for Biomedical Research, University of Birmingham, Birmingham B15 2TT, United Kingdom. ricky.bhogal@uhb.nhs.uk
Telephone: +44-121-4155739
Received: May 1, 2017
Peer-review started: May 5, 2017
First decision: June 7, 2017
Revised: June 19, 2017
Accepted: July 12, 2017
Article in press: July 12, 2017
Published online: December 28, 2017
Processing time: 237 Days and 20.1 Hours
Core Tip

Core tip: Liver sinusoidal endothelial cells autophagy regulates liver ischaemia reperfusion injury and this process can be targeted for therapeutic benefit using normothermic machine liver perfusion.