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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 14, 2017; 23(34): 6339-6349
Published online Sep 14, 2017. doi: 10.3748/wjg.v23.i34.6339
Published online Sep 14, 2017. doi: 10.3748/wjg.v23.i34.6339
P2Y1R is involved in visceral hypersensitivity in rats with experimental irritable bowel syndrome
Jie Wu, Yan Cheng, Dong Liu, Jun Zhang, Department of Gastroenterology, The Second Affiliated Hospital of School of Medicine, Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province, China
Rong Zhang, Department of Gastroenterology, Shaanxi Provincial People’s Hospital, Xi’an 710068, Shaanxi Province, China
Yu-Mei Luo, Department of Gastroenterology, The First Affiliated Hospital of School of Medicine, Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
Kun-Lun Chen, Song Ren, Fourth Cadre Ward, The Second Affiliated Hospital of School of Medicine, Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province, China
Author contributions: Wu J and Zhang J designed the research; Wu J, Cheng Y, Luo YM and Chen KL performed the research; Zhang R and Ren S contributed new reagents or analytic tools; Liu D analyzed the data; Wu J and Zhang J wrote the paper.
Supported by MIMS (Shanghai) Ltd. of China , No. IDF-2013-07 .
Institutional review board statement: This study was approved by the Institutional Review Board of Medicine College of Xi’an Jiaotong University.
Institutional animal care and use committee statement: The study was approved by Ethical Committee of Xi’an Jiaotong University.
Conflict-of-interest statement: None declared.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Jun Zhang, Department of Gastroenterology, The Second Affiliated Hospital of School of Medicine, Xi’an Jiaotong University, No. 157 Xiwu Road, Xi’an 710004, Shaanxi Province, China. junzh3z@163.com
Telephone: +86-13572955788 Fax: +86-29-87679272
Received: March 28, 2017
Peer-review started: April 1, 2017
First decision: April 26, 2017
Revised: May 15, 2017
Accepted: June 19, 2017
Article in press: June 19, 2017
Published online: September 14, 2017
Processing time: 169 Days and 18.3 Hours
Peer-review started: April 1, 2017
First decision: April 26, 2017
Revised: May 15, 2017
Accepted: June 19, 2017
Article in press: June 19, 2017
Published online: September 14, 2017
Processing time: 169 Days and 18.3 Hours
Core Tip
Core tip: P2Y1R is believed to be part of a high-sensitivity response to mechanical stimulation but whether it is involved in visceral hypersensitivity of irritable bowel syndrome is discussing. We detected its expression in the colon of a rat model of irritable bowel syndrome, and explored its regulatory role in visceral hypersensitivity with a specific agonist and an antagonist. The abdominal withdrawal reflex and electromyography tests showed effective changes after intervention. It was interesting to note that in case of combined treatment of the two drugs, the antagonist showed higher effects, which indicated that other P2 receptors might be involved in the hypersensitivity of irritable bowel syndrome.