Hummel M, Knappenberger T, Reilly M, Whiteside GT. Pharmacological evaluation of NSAID-induced gastropathy as a "Translatable" model of referred visceral hypersensitivity. World J Gastroenterol 2017; 23(33): 6065-6076 [PMID: 28970722 DOI: 10.3748/wjg.v23.i33.6065]
Corresponding Author of This Article
Michele Hummel, PhD, Trevena, Inc., 1018 West 8th Avenue, Suite A, King of Prussia, PA 19406. United States. mhummel@trevena.com
Research Domain of This Article
Behavioral Sciences
Article-Type of This Article
Basic Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Sep 7, 2017; 23(33): 6065-6076 Published online Sep 7, 2017. doi: 10.3748/wjg.v23.i33.6065
Pharmacological evaluation of NSAID-induced gastropathy as a "Translatable" model of referred visceral hypersensitivity
Michele Hummel, Terri Knappenberger, Meghan Reilly, Garth T Whiteside
Michele Hummel, Terri Knappenberger, Meghan Reilly, Garth T Whiteside, Purdue Pharma L.P., Discovery Research, Cranbury, NJ 08512, United States
Author contributions: Hummel M and Whiteside GT equally conceptualized study design, analysis, and interpretation of study results; Hummel M wrote the manuscript; Knappenberger T collected and analyzed the data; Reilly M collected rotarod data and prepared the figures depicting the data.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Purdue Institutional Animal Care and Use Committee (IACUC Protocol number: 2014-100) in accordance with the NIH Guide for the Care and Use of Laboratory Animals and the Ethical Guidelines of the International Association for the Study of Pain (www.iasp-pain.org) and are reported in accordance with the ARRIVE guidelines (www.nc3rs.org.uk). All efforts were made to minimize the number of animals used and to avoid any undue pain.
Conflict-of-interest statement: There are no conflicts of interests with any of the authors.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Michele Hummel, PhD, Trevena, Inc., 1018 West 8th Avenue, Suite A, King of Prussia, PA 19406. United States. mhummel@trevena.com
Received: February 2, 2017 Peer-review started: February 8, 2017 First decision: May 12, 2017 Revised: May 31, 2017 Accepted: July 12, 2017 Article in press: July 12, 2017 Published online: September 7, 2017 Processing time: 217 Days and 4.2 Hours
Core Tip
Core tip: Recently, standard animal models of pain have been vehemently challenged for their inability to successfully predict human clinical outcomes. Further, few animal models have been represented with reasonable translational value for conditions presenting with visceral pain. Non-steroidal anti-inflammatory drug -induced gastropathy represents a translatable model of visceral hypersensitivity in which several pain targets have demonstrated reliable sensitivity when assayed. Further, this model is robust enough that proper pharmacological evaluation can be conducted. Overall, this model has the potential to efficiently triage molecules with pain-attenuating properties for their utility in gastrointestinal disorders that include pain as a hallmark symptom.
