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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 28, 2017; 23(32): 5945-5953
Published online Aug 28, 2017. doi: 10.3748/wjg.v23.i32.5945
Published online Aug 28, 2017. doi: 10.3748/wjg.v23.i32.5945
Changes with aging in gastric biomarkers levels and in biochemical factors associated with Helicobacter pylori infection in asymptomatic Chinese population
Jin-Hua Shan, Department of Gerontology and Geriatrics, the First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
Xiao-Juan Bai, Lu-Lu Han, Department of Gerontology and Geriatrics, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China
Yuan Yuan, Department of Tumor Research, the First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
Xue-Feng Sun, Department of Kidney, General Hospital of Chinese People’s Liberation Army, Beijing 100853, China
Author contributions: Shan JH and Bai XJ conceptualized and designed the study; Shan JH and Han LL collected the data; Shan JH and Bai XJ performed analysis and interpretation of the data; Shan JH drafted the manuscript; Bai XJ and Sun XF obtained funding support; Yuan Y provided administrative, technical and material support.
Supported by the National Basic Research Program of China (973 Program) , No. 2007CB507405, No. 2013CB530803 and No. 2013CB530804 .
Institutional review board statement: This study was reviewed and approved by the Medical Ethics Committees of the General Hospital of Chinese People’s Liberation Army and China Medical University.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: There are no conflicts of interest to report.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Xiao-Juan Bai, Department of Gerontology and Geriatrics, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China. baixj@sj-hospital.org
Telephone: +86-24-23516346
Received: April 14, 2017
Peer-review started: April 17, 2017
First decision: May 16, 2017
Revised: May 29, 2017
Accepted: July 12, 2017
Article in press: July 12, 2017
Published online: August 28, 2017
Peer-review started: April 17, 2017
First decision: May 16, 2017
Revised: May 29, 2017
Accepted: July 12, 2017
Article in press: July 12, 2017
Published online: August 28, 2017
Core Tip
Core tip: Our study showed that in an entire healthy population, levels of serum pepsinogen (PG) II increased while PGI/PGII declined with age. We discovered that Helicobacter pylori (H. pylori) infection had an effect on raising levels of low-density lipoprotein cholesterol to increase the risk of atherosclerosis in males, especially those who are elderly. We also found that age, H. pylori infection, serum levels of renal function indicators and fasting blood glucose (FBG) were associated with levels of serum PGs and gastrin; it was assumed that they may influence the secretory function of gastric mucosa and that abnormal serum levels of FBG and renal function might participate in the occurrence and development of gastric diseases.