Basic Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 28, 2017; 23(32): 5887-5894
Published online Aug 28, 2017. doi: 10.3748/wjg.v23.i32.5887
Comparison between tocotrienol and omeprazole on gastric growth factors in stress-exposed rats
Mohd Fahami Nur Azlina, Hj Mohd Saad Qodriyah, Kien Hui Chua, Yusof Kamisah
Mohd Fahami Nur Azlina, Hj Mohd Saad Qodriyah, Yusof Kamisah, Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia
Kien Hui Chua, Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia
Author contributions: Nur Azlina MF, Qodriyah HMS, Chua KH and Kamisah Y designed the research; Nur Azlina MF performed the research and wrote the paper.
Supported by Universiti Kebangsaan Malaysia Research Fund, No. UKM-DLP-066-2011 and No. FF-032-2012.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of Universiti Kebangsaan Malaysia (UKMAEC approval number: 354/2011).
Conflict-of-interest statement: The authors have no conflict of interests to declare.
Data sharing statement: No additional data is available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Mohd Fahami Nur Azlina, DVM, MMedSC, PhD, Associate Professor, Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia. nurazlinamf@ukm.edu.my
Telephone: +603-91459574 Fax: +603-91459547
Received: December 23, 2016
Peer-review started: December 28, 2016
First decision: April 21, 2017
Revised: May 8, 2017
Accepted: July 22, 2017
Article in press: July 24, 2017
Published online: August 28, 2017
Core Tip

Core tip: During the process of ulcer healing, growth factors such as epidermal growth factor, transforming growth factor-alpha, basic fibroblast growth factor and vascular endothelial growth factor acts by activating the migration of cells from the edge of the ulcer and cell proliferation together with the formation of granulation tissue and angiogenesis. Rats exposed to stress develop gastric mucosal ulcers and changes in expression of these growth factors surrounding the ulcers had been reported. Tocotrienol effects on gastric mucosal growth factors were compared to those by omeprazole in this study. The findings suggest that in contrast with omeprazole, tocotrienol has a protective effect on the gastric mucosa through its effect on these growth factors.