Case Control Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 7, 2017; 23(29): 5364-5370
Published online Aug 7, 2017. doi: 10.3748/wjg.v23.i29.5364
Genetic polymorphisms of MAFK, encoding a small Maf protein, are associated with susceptibility to ulcerative colitis in Japan
Tomiyasu Arisawa, Masakatsu Nakamura, Toshimi Otsuka, Wu Jing, Naoko Sakurai, Hikaru Takano, Tasuku Hayashi, Masafumi Ota, Tomoe Nomura, Ranji Hayashi, Takeo Shimasaki, Tomomitsu Tahara, Tomoyuki Shibata
Tomiyasu Arisawa, Masakatsu Nakamura, Toshimi Otsuka, Wu Jing, Naoko Sakurai, Hikaru Takano, Tasuku Hayashi, Masafumi Ota, Tomoe Nomura, Ranji Hayashi, Takeo Shimasaki, Department of Gastroenterology, Kanazawa Medical University, Ishikawa 920-0293, Japan
Tomomitsu Tahara, Tomoyuki Shibata, Department of Gastroenterology, Fujita Health University, Kutsukake-cho, Toyoake 470-1192, Japan
Author contributions: Arisawa T analyzed the data, wrote the paper and was responsible for the conception of the study and designed the study; Nakamura M, Otsuka T, Sakurai N, Takano H, Hayashi T, Ota M, Nomura T and Hayashi R obtained the samples and the data; Jing W and Shimasaki T determined genotype; Tahara T and Shibata T participated in the design of the study.
Institutional review board statement: The study was approved by the Ethics Committee of Kanazawa Medical University (Uchinada-machi, Japan) and Fujita Health University (Toyoake, Japan).
Informed consent statement: All patients gave informed consent.
Conflict-of-interest statement: There are no conflicts of interest.
Data sharing statement: Technical appendix, statistical code and dataset available from the corresponding author at tarisawa@kanazawa-med.ac.jp. Informed consent form participants for data sharing was not obtained but the presented data are anonymized and risk of identification is low.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Tomiyasu Arisawa, MD, PhD, Department of Gastroenterology, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Ishikawa 920-0293, Japan. tarisawa@kanazawa-med.ac.jp
Telephone: +81-76-2188154 Fax: +81-76-2860892
Received: January 24, 2017
Peer-review started: February 1, 2017
First decision: March 3, 2014
Revised: March 14, 2014
Accepted: July 4, 2017
Article in press: July 4, 2017
Published online: August 7, 2017
Processing time: 194 Days and 18.4 Hours
Core Tip

Core tip: We investigated the association between maf protein K (MAFK), polymorphisms and ulcerative colitis in Japan. Both rs4268033 and rs3735656 minor allele homozygotes were significantly associated with the susceptibility to ulcerative colitis (UC) development. In addition, rs4268033 minor allele homozygote was significantly associated with all phenotypes of UC except the phenotype with younger age onset. Our results provided the first evidence that MAFK genetic polymorphisms were significantly associated with the susceptibility to UC development.