Basic Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 28, 2017; 23(28): 5167-5178
Published online Jul 28, 2017. doi: 10.3748/wjg.v23.i28.5167
Fibroblast-derived CXCL12/SDF-1α promotes CXCL6 secretion and co-operatively enhances metastatic potential through the PI3K/Akt/mTOR pathway in colon cancer
Jia-Chi Ma, Xiao-Wen Sun, He Su, Quan Chen, Tian-Kang Guo, Yuan Li, Xiao-Chang Chen, Jin Guo, Zhen-Qiang Gong, Xiao-Dan Zhao, Jian-Bo Qi
Jia-Chi Ma, He Su, Quan Chen, Tian-Kang Guo, Yuan Li, Xiao-Chang Chen, Jin Guo, Zhen-Qiang Gong, Xiao-Dan Zhao, Jian-Bo Qi, Department of General Surgery, Gansu Provincial People’s Hospital, Lanzhou 730000, Gansu Province, China
Xiao-Wen Sun, Department of Dermatology, The First Hospital of Tianshui, Tianshui 741000, Gansu Province, China
Xiao-Chang Chen, Jin Guo, Zhen-Qiang Gong, Xiao-Dan Zhao, Ningxia Medical University, Yinchuan 750000, Ningxia Hui Autonomous Region, China
Jian-Bo Qi, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, Gansu Province, China
Author contributions: Ma JC and Sun XW contributed equally to this article; Su H, Chen Q and Guo TK conceived and designed the study; Li Y, Chen XC, Gong ZQ, Zhao XD and Qi JB performed the experiments; Ma JC, Su H, Chen Q, Chen XC, Guo J and Gong ZQ analyzed and interpreted the data; Ma JC and Sun XW drafted the manuscript.
Supported by National Natural Science Foundation of China, No. 81260325 (to Ma JC).
Conflict-of-interest statement: The authors declare that they have no competing interests.
Data sharing statement: No additional unpublished data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Jia-Chi Ma, PhD, Department of General Surgery, Gansu Provincial People’s Hospital, 204 Dong Gang West Road, Lanzhou 730000, Gansu Province, China. tsmjc@hotmail.com
Telephone: +86-931-8281382
Received: February 10, 2017
Peer-review started: February 14, 2017
First decision: March 30, 2017
Revised: April 13, 2017
Accepted: May 9, 2017
Article in press: May 9, 2017
Published online: July 28, 2017
Processing time: 168 Days and 12.1 Hours
Core Tip

Core tip: This study has provided the first report of fibroblast-derived CXCL12 enhancement of CXCL6 secretion in colon cancer cells, and of both CXCL12 and CXCL6 co-operatively regulating metastasis through the PI3K/Akt/mTOR signaling pathway. Blockage of this pathway may be a potential anti-metastatic therapeutic target for patients with colon cancer. Our work might encourage further investigation into more potent angiogenesis modulating agents to improve the effectiveness of colon cancer therapies.