Basic Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 21, 2017; 23(27): 4910-4919
Published online Jul 21, 2017. doi: 10.3748/wjg.v23.i27.4910
Generation of glyceraldehyde-derived advanced glycation end-products in pancreatic cancer cells and the potential of tumor promotion
Takanobu Takata, Tadashi Ueda, Akiko Sakasai-Sakai, Masayoshi Takeuchi
Takanobu Takata, Tadashi Ueda, Akiko Sakasai-Sakai, Masayoshi Takeuchi, Department of Advanced Medicine, Medical Research Institute, Kanazawa Medical University, Uchinada, Ishikawa 920-0293, Japan
Author contributions: Takata T and Takeuchi M designed the research; Takata T performed the research; Takeuchi M contributed the reagents that were indispensable for this investigation; Takata T, Ueda T and Sakasai-Sakai A analyzed the data; Takata T and Takeuchi M wrote the paper.
Supported by Japan Society for the Promotion of Science (JSPS) KAKENHI Grant, No. 25282029, No. 26750056, and No. 16H01811; and a grant from the Hokkoku Foundation for Cancer Research.
Institutional review board statement: This study does not need to be reviewed and approved by the Kanazawa Medical University because the experiment only used an established cell line (PANC-1) and the cell line was not genetically modified.
Conflict-of-interest statement: The authors declare no competing financial interests.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Takanobu Takata, PhD, Department of Advanced Medicine, Medical Research Institute, Kanazawa Medical University, Uchinada, Ishikawa 920-0293, Japan. takajjjj@kanazawa-med.ac.jp
Telephone: +81-76-2862211 Fax: +81-76-2863652
Received: March 24, 2017
Peer-review started: April 10, 2017
First decision: April 26, 2017
Revised: May 10, 2017
Accepted: June 18, 2017
Article in press: June 19, 2017
Published online: July 21, 2017
Processing time: 117 Days and 18.4 Hours
Core Tip

Core tip: The mechanisms promoting pancreatic ductal adenocarcinoma (PDAC) in the pancreas of Type 2 diabetes mellitus patients have not yet been elucidated. We hypothesized that glyceraldehyde (GA)-derived advanced glycation-end products (GA-AGEs) promote PDAC. PANC-1 cells were treated with GA, which induced the production of intracellular GA-AGEs and cell death. The high-molecular-weight complexes of heat shock proteins were produced after GA treatment in a dose-dependent manner. GA-AGEs-bovine serum albumin promoted the proliferation of PANC-1 cells. Although intracellular GA-AGEs induce pancreatic cancer cell death, their secretion and release may promote the proliferation of other pancreatic cancer cells.