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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 14, 2017; 23(26): 4788-4795
Published online Jul 14, 2017. doi: 10.3748/wjg.v23.i26.4788
Published online Jul 14, 2017. doi: 10.3748/wjg.v23.i26.4788
Endoscopy is of low yield in the identification of gastrointestinal neoplasia in patients with dermatomyositis: A cross-sectional study
Trilokesh D Kidambi, James W Ostroff, Jonathan P Terdiman, Jeffrey K Lee, Division of Gastroenterology, University of California, San Francisco, CA 94115, United States
Gabriela Schmajuk, Andrew J Gross, Division of Rheumatology, University of California, San Francisco, San Francisco, CA 94115, United States
Gabriela Schmajuk, Division of Rheumatology, San Francisco Veterans Affairs Medical Center, San Francisco, CA 94115, United States
Author contributions: Kidambi TD study concept and design, data acquisition, analysis and interpretation, drafting of manuscript, critical revision of manuscript; He has approved the final draft of the manuscript; Schmajuk G study concept, data acquisition, critical revision of manuscript. She has approved the final draft of the manuscript; Gross AJ study concept, critical revision of manuscript. He has approved the final draft of the manuscript; Terdiman JP study concept, critical revision of manuscript. He has approved the final draft of the manuscript; Lee JK study concept and design, data interpretation, drafting of manuscript, critical revision of manuscript, study supervision. He has approved the final draft of the manuscript; all authors contributed to this manuscript.
Supported by National Cancer Institute , No. K07CA212057 ; and American Gastroenterological Association .
Institutional review board statement: The study was approved by the University of California, San Francisco Institutional Review Board.
Informed consent statement: Waived by institutional review board given retrospective nature of the study.
Conflict-of-interest statement: No potential conflicts of interest relevant to this article were reported.
Data sharing statement: No additional data available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Jeffrey K Lee, MD, MAS, Division of Gastroenterology, University of California, 1701 Divisadero, San Francisco, CA 94115, United States. jeff.lee@ucsf.edu
Telephone: +1-415-5024444
Received: March 23, 2017
Peer-review started: March 28, 2017
First decision: May 10, 2017
Revised: May 16, 2017
Accepted: June 9, 2017
Article in press: June 9, 2017
Published online: July 14, 2017
Peer-review started: March 28, 2017
First decision: May 10, 2017
Revised: May 16, 2017
Accepted: June 9, 2017
Article in press: June 9, 2017
Published online: July 14, 2017
Core Tip
Core tip: Dermatomyositis is associated with an increased risk of gastrointestinal (GI) malignancies based on large-population based studies. These prior studies utilized code-based search strategies and did not perform individual chart review. The yield of endoscopy in this patient population is not known. In this study, endoscopy identified no cases of malignancy and was of low yield, likely similar to the general population, in the identification of pre-malignant findings. Code-based searched strategies were inaccurate in the identification of dermatomyositis, calling into question the results of prior population-based studies. The association between increased GI malignancy and dermatomyositis may be lower than previously reported.