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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 14, 2017; 23(26): 4744-4751
Published online Jul 14, 2017. doi: 10.3748/wjg.v23.i26.4744
Published online Jul 14, 2017. doi: 10.3748/wjg.v23.i26.4744
Effect of EPEC endotoxin and bifidobacteria on intestinal barrier function through modulation of toll-like receptor 2 and toll-like receptor 4 expression in intestinal epithelial cell-18
Xia Yang, Xian-Chun Gao, Jun Liu, Hong-Yu Ren, Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China
Author contributions: Yang X and Gao XC contributed equally as co-first authors; Ren HY conceived and designed the experiments; Yang X and Gao XC performed the majority of experiments, analyzed the data and wrote the paper; Ren HY and Liu J provided reagents, materials and analytical tools; all authors read and approved the final manuscript.
Supported by Medjaden Academy and Research Foundation for Young Scientists , No. MJA20170410 .
Institutional review board statement: This study was approved by the Institutional Review Board of Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China.
Conflict-of-interest statement: None of the authors have any potential conflicts of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Hong-Yu Ren, MD, PhD, Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Road, Wuhan 430022, Hubei Province, China. hongyur@hotmail.com
Telephone: +86-27-85726381
Received: February 10, 2017
Peer-review started: February 11, 2017
First decision: March 16, 2017
Revised: April 23, 2017
Accepted: May 19, 2017
Article in press: May 19, 2017
Published online: July 14, 2017
Peer-review started: February 11, 2017
First decision: March 16, 2017
Revised: April 23, 2017
Accepted: May 19, 2017
Article in press: May 19, 2017
Published online: July 14, 2017
Core Tip
Core tip: Toll-like receptor (TLRs) are key components of the innate immune system that trigger antimicrobial host defense responses. EPEC promoted the expression of toll-like receptor 2 (TLR2) and TLR4 and increased cell membrane permeability, where as bifidobacteria inhibited the expression of TLR2 and TLR4 and prevented TLR-mediated inflammation. Therefore, bifidobacteria can potentially play a protective role by inhibiting inflammation and preventing penetration of pathogenic bacteria in patients with inflammatory bowel disease.