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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 14, 2017; 23(26): 4669-4674
Published online Jul 14, 2017. doi: 10.3748/wjg.v23.i26.4669
Published online Jul 14, 2017. doi: 10.3748/wjg.v23.i26.4669
Impact of hepatitis C oral therapy in portal hypertension
Diogo Libânio, Department of Gastroenterology, Instituto Português de Oncologia do Porto, 4200-072 Porto, Portugal
Rui Tato Marinho, Department of Gastroenterology and Hepatology, Centro Hospitalar de Lisboa Norte/Hospital Santa Maria, 1649-035 Lisbon, Portugal
Rui Tato Marinho, Faculty of Medicine, University of Lisbon, 1600-276 Lisbon, Portugal
Author contributions: Libânio D and Marinho RT designed and wrote this manuscript.
Conflict-of-interest statement: The authors declare no conflict of interest of any kind regarding this manuscript
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Diogo Libânio, MD, Department of Gastroenterology, Instituto Português de Oncologia do Porto, Rua Dr. António Bernardino de Almeida, 4200-072 Porto, Portugal. diogo.monteiro@ipoporto.min-saude.pt
Telephone: +35-191-0288892
Received: January 22, 2017
Peer-review started: January 24, 2017
First decision: March 16, 2017
Revised: March 28, 2017
Accepted: May 19, 2017
Article in press: May 19, 2017
Published online: July 14, 2017
Processing time: 170 Days and 10.2 Hours
Peer-review started: January 24, 2017
First decision: March 16, 2017
Revised: March 28, 2017
Accepted: May 19, 2017
Article in press: May 19, 2017
Published online: July 14, 2017
Processing time: 170 Days and 10.2 Hours
Core Tip
Core tip: Hepatitis C is associated with significant morbidity and mortality, mainly through portal hypertension complications. Hepatitis C treatment is associated with improvement of liver function and fibrosis, better quality of life and reduced mortality. The knowledge of the impact of viral clearance on portal hypertension is also relevant because it greatly influences clinical outcomes and can influence management after treatment. Several studies show that the benefits on portal hypertension are higher if treatment is delivered before clinically significant portal hypertension is developed, encouraging timely and early treatment with the highly efficacious and safe direct antiviral agents.