Moon HS, Yun GY, Kim JS, Eun HS, Kang SH, Sung JK, Jeong HY, Song KS. Risk factors for metachronous gastric carcinoma development after endoscopic resection of gastric dysplasia: Retrospective, single-center study. World J Gastroenterol 2017; 23(24): 4407-4415 [PMID: 28706423 DOI: 10.3748/wjg.v23.i24.4407]
Corresponding Author of This Article
Jae Kyu Sung, MD, PhD, Department of Internal Medicine, Chungnam National University Hospital, Chungnam National University School of Medicine, 282 Munhwa-ro, Jung-gu, Daejeon 35015, South Korea. jksung69@cnuh.co.kr
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Jun 28, 2017; 23(24): 4407-4415 Published online Jun 28, 2017. doi: 10.3748/wjg.v23.i24.4407
Risk factors for metachronous gastric carcinoma development after endoscopic resection of gastric dysplasia: Retrospective, single-center study
Hee Seok Moon, Gee Young Yun, Ju Seok Kim, Hyuk Soo Eun, Sun Hyung Kang, Jae Kyu Sung, Hyun Yong Jeong, Kyu-Sang Song
Hee Seok Moon, Gee Young Yun, Ju Seok Kim, Hyuk Soo Eun, Sun Hyung Kang, Jae Kyu Sung, Hyun Yong Jeong, Department of Internal Medicine, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon 35015, South Korea
Kyu-Sang Song, Department of Pathology, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon 35015, South Korea
Author contributions: Moon HS interpreted and analyzed the data and wrote the manuscript; Sung JK designed, organized, and supervised writing of the manuscript; Kang SH and Jeong HY helped with data interpretation that was used in the current study; Yun GY and Kim JS provided input and organized the data for statistical analysis; Eun HS helped with data analysis; Song KS confirmed the pathology; all authors approved the final version of the manuscript.
Institutional review board statement: The study was reviewed and approved by the Chungnam National University Hospital Institutional Review Board (IRB file No. 2017-01-033).
Informed consent statement: This study is a retrospective study using medical records, and personal information protection measures are appropriately established so that the informed consent of the subject can be exempted.
Conflict-of-interest statement: We have no conflicts of interest regarding the current paper.
Data sharing statement: No additional data are available
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Jae Kyu Sung, MD, PhD, Department of Internal Medicine, Chungnam National University Hospital, Chungnam National University School of Medicine, 282 Munhwa-ro, Jung-gu, Daejeon 35015, South Korea. jksung69@cnuh.co.kr
Telephone: +82-42-2807186 Fax: +82-42-2544553
Received: February 16, 2017 Peer-review started: February 17, 2017 First decision: March 22, 2017 Revised: April 4, 2017 Accepted: May 19, 2017 Article in press: May 19, 2017 Published online: June 28, 2017 Processing time: 129 Days and 23.1 Hours
Core Tip
Core tip: Gastric dysplasia is considered a premalignant lesion that can become malignant. Thus, endoscopic resection is preferred not only for the removal of these lesions but also for exact diagnosis. In our study, we investigated the relationship between the occurrence of synchronous and metachronous lesions after endoscopic treatment of gastric dysplasia and various clinical factors during the follow-up period. The incidence rates of synchronous and metachronous neoplasms after endoscopic resection of gastric dysplasia were 12.1% and 13.8%, respectively. In the multivariate analysis, age of < 60 years and intestinal metaplasia were independent risk factors of synchronous neoplasm. For metachronous neoplasm, especially metachronous gastric adenocarcinoma, independent risk factors were male sex, intestinal metaplasia, and high-grade dysplasia.
