Basic Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 7, 2017; 23(21): 3815-3824
Published online Jun 7, 2017. doi: 10.3748/wjg.v23.i21.3815
Prevalence of IFNL3 rs4803217 single nucleotide polymorphism and clinical course of chronic hepatitis C
Bogna Świątek-Kościelna, Ewelina Kałużna, Ewa Strauss, Jerzy Nowak, Iwona Bereszyńska, Ewelina Gowin, Jacek Wysocki, Jolanta Rembowska, Dominika Barcińska, Iwona Mozer-Lisewska, Danuta Januszkiewicz-Lewandowska
Bogna Świątek-Kościelna, Ewelina Kałużna, Ewa Strauss, Jerzy Nowak, Jolanta Rembowska, Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland, 60-479 Poznan, Poland
Ewa Strauss, Department of General and Vascular Surgery, Poznan University of Medical Sciences, 61-848 Poznan, Poland
Iwona Bereszyńska, Iwona Mozer-Lisewska, Department of Infectious Diseases, Poznan University of Medical Sciences, 61-288 Poznan, Poland
Ewelina Gowin, Department of Family Medicine, Poznan University of Medical Sciences, 60-355 Poznan, Poland
Jacek Wysocki, Department of Preventive Medicine, Poznan University of Medical Sciences, 60-179 Poznan, Poland
Dominika Barcińska, Department of Medical Diagnostics, 60-595 Poznan, Poland
Danuta Januszkiewicz-Lewandowska, Department of Pediatric Oncology, Hematology and Bone Marrow Transplantation, Poznan University of Medical Sciences, 60-572 Poznan, Poland
Danuta Januszkiewicz-Lewandowska, Department of Medical Diagnostics, 60-595 Poznan, Poland
Author contributions: Świątek-Kościelna B, Kałużna E and Strauss E contributed equally to this work; Świątek-Kościelna B, Kałużna E, Nowak J, Bereszyńska I, Gowin E, Wysocki J, Mozer-Lisewska I and Januszkiewicz-Lewandowska D substantially contributed to the conception and design of the study, samples and data collection and interpretation of results; Świątek-Kościelna B, Kałużna E, Rembowska J and Barcińska D performed the experiments; Świątek-Kościelna B and Strauss E analyzed the results; all authors drafted the article and made critical revisions related to the intellectual content of the manuscript, and approved the final version of the article to be published; Świątek-Kościelna B, Kałużna E and Strauss E contributed equally to this work.
Institutional review board statement: The study was approved by the Bioethics Committee of the Poznan University of Medical Sciences (No. 650/12).
Conflict-of-interest statement: All authors declare no conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Danuta Januszkiewicz-Lewandowska, MD, PhD, Professor, Department of Pediatric Oncology, Hematology and Bone Marrow Transplantation, Poznan University of Medical Sciences, Szpitalna 27/33, 60-572 Poznan, Poland. danuta.januszkiewicz@ump.edu.pl
Telephone: +48-60-1781821 Fax: +48-61-8233235
Received: January 27, 2017
Peer-review started: February 12, 2017
First decision: March 3, 2017
Revised: March 17, 2017
Accepted: May 4, 2017
Article in press: May 4, 2017
Published online: June 7, 2017
Processing time: 130 Days and 9.2 Hours
Core Tip

Core tip: The rs4803217 single nucleotide polymorphism of IFNL3 (IL28B) gene, which encodes, interferon lambda 3 (interleukin 28B), has been proposed as a causal variant that may influence hepatitis C virus (HCV) clearance. In the present study it was found that rs4803217 is a strong and independent predictor of sustained virological response and relapse in HCV genotype 1 infected chronic hepatitis C patients treated with pegylated interferon alpha and ribavirin. Moreover, it was indicated that rs4803217 seems to be much better predictor of therapy outcome than well-establish IFNL3 SNPs (rs12979860, rs8099917 and rs12980275).