Randomized Controlled Trial
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 14, 2017; 23(18): 3356-3366
Published online May 14, 2017. doi: 10.3748/wjg.v23.i18.3356
Low-FODMAP diet reduces irritable bowel symptoms in patients with inflammatory bowel disease
Natalia Pedersen, Dorit Vedel Ankersen, Maria Felding, Henrik Wachmann, Zsuzsanna Végh, Line Molzen, Johan Burisch, Jens Rikardt Andersen, Pia Munkholm
Natalia Pedersen, Department of Gastroenterology, Slagelse Hospital, 4200 Slagelse, Denmark
Dorit Vedel Ankersen, Line Molzen, Johan Burisch, Pia Munkholm, Gastroenterology Unit, North Zealand Hospital, 3600 Frederikssund, Denmark
Maria Felding, Jens Rikardt Andersen, Department of Nutrition, Exercise and Sports, University of Copenhagen, 2100 Copenhagen, Denmark
Henrik Wachmann, Department of Statistics, Larix A/S, 2730 Herlev, Denmark
Zsuzsanna Végh, First Department of Medicine, Semmelweis University, 1083 Budapest, Hungary
Author contributions: Pedersen N and Ankersen DV contributed equally to this work; Pedersen N, Ankersen DV, Felding M, Andersen JR and Munkholm P designed the research; Pedersen N, Ankersen DV, Felding M performed the research; Ankersen DV and Felding M educated patients in the use of LFD; Pedersen N, Ankersen DV and Wachmann H analysed the data; Pedersen N, Ankersen DV wrote the paper, which was critically revised by all co-authors; all the authors contributed to this manuscript.
Institutional review board statement: The study was approved by Ethics Committee of Science, Denmark (protocol H-2-2012-05/38987).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Data sharing statement: Data set are available from the corresponding author (natalia.pedersen@regionh.dk). The Danish Data Protection Agency approved the study design for ensuring the protection of the data. The presented data are anonymized and the risk of identification is low. No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Natalia Pedersen, Department of Gastroenterology, Slagelse Hospital, Ingemannsvej 24, 4200 Slagelse, Denmark. natalia.pedersen@zeniavej.dk
Telephone: +45-29919548 Fax: +45-29919547
Received: November 15, 2016
Peer-review started: November 17, 2016
First decision: December 24, 2016
Revised: January 24, 2017
Accepted: March 20, 2017
Article in press: March 20, 2017
Published online: May 14, 2017
Core Tip

Core tip: This is one of the first randomized controlled studies showing that low-FODMAP diet had ameliorative effect on irritable bowel syndrome (IBS)-like symptoms in a Danish inflammatory bowel disease (IBD) population in remission. The IBD quality of life were also improved on the same diet. Based on the results of this study, a low-FODMAP diet could be recommended for IBD patients in remission who are experiencing IBS-like symptoms. The diet requires guidance from a dietician for closely monitoring of the nutritional adequacy with dietary restriction.