Retrospective Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 14, 2017; 23(18): 3301-3308
Published online May 14, 2017. doi: 10.3748/wjg.v23.i18.3301
Benefit of neoadjuvant concurrent chemoradiotherapy for locally advanced perihilar cholangiocarcinoma
Jang Han Jung, Hyun Jik Lee, Hee Seung Lee, Jung Hyun Jo, In Rae Cho, Moon Jae Chung, Jeong Youp Park, Seung Woo Park, Si Young Song, Seungmin Bang
Jang Han Jung, Division of Gastroenterology, Department of Internal Medicine, Hallym University Dongtan Sacred Heart Hospital, 7, Keunjaebong-gil, Hwaseong-si, Gyeonggi-do 18450, South Korea
Hyun Jik Lee, Hee Seung Lee, Jung Hyun Jo, In Rae Cho, Moon Jae Chung, Jeong Youp Park, Seung Woo Park, Si Young Song, Seungmin Bang, Division of Gastroenterology, Department of Internal Medicine and Yonsei Institute of Gastroenterology, Yonsei University College of Medicine, Seoul 03722, South Korea
Author contributions: Jung JH and Bang S contributed study design, data analysis and writing of the manuscript; Lee HJ, Lee HS, Jo JH and Cho IR contributed data analysis; Chung MJ, Park JY, Park SW and Song SY contributed to draft the manuscript and helped the literature review.
Institutional review board statement: The institutional review board of Severance Hospital approves this study (IRB 2016-2480-001).
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: We have no financial relationships to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Seungmin Bang, MD, PhD, Division of Gastroenterology, Department of Internal Medicine and Yonsei Institute of Gastroenterology, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, South Korea. bang7028@yuhs.ac
Telephone: +82-2-22281995 Fax: +82-2-22281995
Received: February 6, 2017
Peer-review started: February 8, 2017
First decision: February 23, 2017
Revised: March 18, 2017
Accepted: April 12, 2017
Article in press: April 12, 2017
Published online: May 14, 2017
Processing time: 97 Days and 14.9 Hours
Core Tip

Core tip: This study is a retrospective study to clarify the role of neoadjuvant concurrent chemoradiotherapy (NACCRT) followed by surgical resection for locally advanced perihilar cholangiocarcinoma (CCA). The median disease free survival (DFS) durations of the neoadjuvant and non-neoadjuvant group were 26.0 and 15.1 mo, respectively (P = 0.91). The median overall survival (OS) durations of the neoadjuvant and non-neoadjuvant groups were 32.9 and 27.1 mo, respectively (P = 0.26). However, the NACCRT group showed a downstaging tendency compared to the non-NACCRT group (P = 0.01). This paper will be helpful in the treatment plan for patients with locally advanced perihilar cholangiocarcinoma, especially NACCRT.