Review
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 7, 2017; 23(17): 3030-3042
Published online May 7, 2017. doi: 10.3748/wjg.v23.i17.3030
Genes, emotions and gut microbiota: The next frontier for the gastroenterologist
Arturo Panduro, Ingrid Rivera-Iñiguez, Maricruz Sepulveda-Villegas, Sonia Roman
Arturo Panduro, Ingrid Rivera-Iñiguez, Maricruz Sepulveda-Villegas, Sonia Roman, Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara, “Fray Antonio Alcalde”, Guadalajara 44280, Jalisco, Mexico
Arturo Panduro, Ingrid Rivera-Iñiguez, Maricruz Sepulveda-Villegas, Sonia Roman, Health Sciences Center, University of Guadalajara, Guadalajara 44280, Jalisco, Mexico
Author contributions: Panduro A conceived the idea, wrote and critically revised the content of this article; Rivera-Iñiguez I performed the literature research, drew the illustrations and drafted the first version of the manuscript paper; Sepulveda-Villegas M performed the literature research, drew the illustrations and wrote the paper; Roman S wrote, integrated the final version and critically revised the article; all authors read and approved the final version.
Supported by Prodep-Universidad de Guadalajara, No. CA-478.
Conflict-of-interest statement: Authors declare no conflict of interest for this article.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Arturo Panduro, MD, PhD, FAASLD, Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara “Fray Antonio Alcalde”, Hospital # 278, Col. El Retiro, Guadalajara, Jalisco 44280, México. apanduro@prodigy.net.mx
Telephone: +52-33-36147743 Fax: +52-33-36147743
Received: January 27, 2017
Peer-review started: February 6, 2017
First decision: March 3, 2017
Revised: March 10, 2017
Accepted: April 12, 2017
Article in press: April 12, 2017
Published online: May 7, 2017
Processing time: 98 Days and 22.3 Hours
Core Tip

Core tip: Even though instincts, emotions, and behavior are evolutionary mechanisms for humans to adapt, dysfunctional genes, chronic negative emotions and gut dysbiosis are high risk factors for different diseases. A deep study of the gene-environmental interactions and the gut-bacteria consortium is a key factor that could help to understand how negative emotions are translated into disease. Physicians do not always consider that emotional factors aggravate disease progression and severity. Therefore, personalized-medicine and genomic-based nutrition strategies may aid in the prevention and reduction in the prevalence of gastrointestinal disorders associated with obesity and negative emotions.