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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 7, 2017; 23(13): 2414-2423
Published online Apr 7, 2017. doi: 10.3748/wjg.v23.i13.2414
Published online Apr 7, 2017. doi: 10.3748/wjg.v23.i13.2414
Proposed criteria to differentiate heterogeneous eosinophilic gastrointestinal disorders of the esophagus, including eosinophilic esophageal myositis
Hiroki Sato, Nao Nakajima, Kazuya Takahashi, Ken-ichi Mizuno, Satoru Hashimoto, Satoshi Ikarashi, Kazunao Hayashi, Yutaka Honda, Junji Yokoyama, Yuichi Sato, Shuji Terai, Division of Gastroenterology and Hepatology, Niigata University Medical and Dental Hospital, Niigata 951-8520, Japan
Hiroki Sato, Division of Gastroenterology and Hepatology, Saiseikai Niigata Daini Hospital, Niigata 950-1104, Japan
Go Hasegawa, Division of Cellular and Molecular Pathology, Department of Cellular Function, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8520, Japan
Author contributions: Sato H designed the research study and wrote the paper; Nakajima N analyzed the RT-PCR data; Takahashi K analyzed the manometry data; Hasegawa G analyzed the histological data and critically revised the manuscript; Mizuno K, Hashimoto S, Ikarashi S, Hayashi K, Honda Y and Yokoyama J collected the clinical data; Sato Y and Terai S critically revised the manuscript; all authors contributed to this manuscript.
Supported by JSPS Grants-in-Aid for Scientific Research , No. 16K19332 ; and Takeda medical research grants .
Conflict-of-interest statement: The authors declare no competing interests.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Hiroki Sato, MD, PhD, Division of Gastroenterology and Hepatology, Niigata University Medical and Dental Hospital, 757-1, Asahimachidori, Chuo-ku, Niigata City, Niigata 951-8510, Japan. pyloki@yahoo.co.jp
Telephone: +81-25-2232207 Fax: +81-25-2230776
Received: November 17, 2016
Peer-review started: November 18, 2016
First decision: February 9, 2017
Revised: February 27, 2017
Accepted: March 15, 2017
Article in press: March 15, 2017
Published online: April 7, 2017
Peer-review started: November 18, 2016
First decision: February 9, 2017
Revised: February 27, 2017
Accepted: March 15, 2017
Article in press: March 15, 2017
Published online: April 7, 2017
Core Tip
Core tip: Eosinophilic esophagitis has long been considered as the only eosinophilic gastrointestinal disorder (EoGD) in the esophagus. However, eosinophilic esophageal myositis, characterized by esophageal symptoms and eosinophilic infiltration in the esophageal muscle layer, has been identified using peroral esophageal muscle biopsy. Combining clinical and histological data, we have defined clinical criteria to differentiate EoGDs in the esophagus.