Retrospective Cohort Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 7, 2017; 23(1): 110-120
Published online Jan 7, 2017. doi: 10.3748/wjg.v23.i1.110
Expression of trefoil factors and TWIST1 in colorectal cancer and their correlation with metastatic potential and prognosis
Akram Yusup, Bailikezi Huji, Cheng Fang, Fei Wang, Tuerxunjiang Dadihan, Hai-Jiang Wang, Halmurat Upur
Akram Yusup, Bailikezi Huji, Hai-Jiang Wang, Department of Gastrointestinal Surgery and Record Room, Affiliated Tumor Hospital, Xin Jiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China
Cheng Fang, Fei Wang, Department of Gastrointestinal Surgery, Xi Jing Digestive Disease Hospital, Fourth Military Medical University, Xi’an 710032, Shaanxi Province, China
Tuerxunjiang Dadihan, Department of Human Anatomy of Preclinical College, Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China
Halmurat Upur, Central Laboratory, Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China
Author contributions: Yusup A, Wang HJ and Upur H conceived and designed the study; Yusup A wrote the first draft of the manuscript; Huji B assisted with the collection of the clinicopathological materials and the overall statistics and analysis of the data; Fang C, Wang F and Dadihan T helped perform experiments such as immunohistochemistry, qRT-PCR and Western blot; all authors read and approved the final manuscript.
Supported by the Natural Science Fund of the Xinjiang Uygur Autonomous Region, No. 2014211C111.
Institutional review board statement: The study design and procedures described below were approved by the Ethics Committee of the Affiliated Tumor Hospital of Xinjiang Medical University (No. W-201401).
Informed consent statement: All patients provided informed written consent prior to their participation.
Conflict-of-interest statement: No conflict of interest exists in the submission of this manuscript.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Halmurat Upur, PhD, Central Laboratory, Xinjiang Medical University, 393 Xinyi Road, Urumqi 830054, Xinjiang Uygur Autonomous Region, China. bilik0731@163.com
Telephone: +86-991-4365765 Fax:+86-991-4365231
Received: August 27, 2016
Peer-review started: August 29, 2016
First decision: September 28, 2016
Revised: October 19, 2016
Accepted: December 2, 2016
Article in press: December 2, 2016
Published online: January 7, 2017
Processing time: 130 Days and 17.2 Hours
Core Tip

Core tip: The expression of trefoil factors (TFFs) and TWIST1 in colorectal cancer (CRC) and their roles in metastasis and survival are unclear. This study involved the preliminary examination of the expression of TFF1, TFF3 and TWIST1 in CRC tissues and different metastasis samples from patients and cell lines. This study also analyzed the relationship between the expression of these proteins and metastatic potential and survival. It can be concluded that the expression of TFF3 and TWIST1 in CRC might be associated with patient survival after curative resection and may play an active role in disease progression. Finally, TFF3 may be correlated to the invasiveness of the CRC.