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©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 7, 2016; 22(5): 1919-1924
Published online Feb 7, 2016. doi: 10.3748/wjg.v22.i5.1919
Published online Feb 7, 2016. doi: 10.3748/wjg.v22.i5.1919
Auxiliary partial liver transplantation for acute liver failure using "high risk" grafts: Case report
Wei-Dong Duan, Xi-Tao Wang, Hong-Guang Wang, Wen-Bin Ji, Hao Li, Jia-Hong Dong, Department of Hepatobiliary Surgery, Chinese PLA General Hospital, Beijing 100853, China
Xi-Tao Wang, School of Medicine, Nankai University, Tianjin 300071, China
Author contributions: Duan WD and Wang XT equally contributed to this article; Duan WD, Wang XT and Dong JH designed the report; Wang HG, Ji WB, Li H performed the genetic analyses; Duan WD, Wang XT and Wang HG collected the patient’s clinical data; Duan WD, Wang XT and Dong JH analyzed the data and wrote the paper.
Supported by National Key Technology R&D Program of China (2012BAI06B01).
Institutional review board statement: The Institutional review board of PLAGH approved this study.
Informed consent statement: The patient gave her written informed consent for institutional-initiated research studies and analyses of clinical outcome studies conforming to our institutional review board guidelines.
Conflict-of-interest statement: There was no conflict of interest to be reported.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Jia-Hong Dong, MD, PhD, FACS, Director, Department of Hepatobiliary Surgery, Chinese PLA General Hospital, Fuxing Road 28, Haidian District, Beijing 100853, China. dongjh301@163.com
Telephone: +86-10-66938030 Fax: +86-10-66936602
Received: July 10, 2015
Peer-review started: July 13, 2015
First decision: August 26, 2015
Revised: September 11, 2015
Accepted: November 9, 2015
Article in press: November 9, 2015
Published online: February 7, 2016
Processing time: 195 Days and 0.3 Hours
Peer-review started: July 13, 2015
First decision: August 26, 2015
Revised: September 11, 2015
Accepted: November 9, 2015
Article in press: November 9, 2015
Published online: February 7, 2016
Processing time: 195 Days and 0.3 Hours
Core Tip
Core tip: The use of a “high risk” organ (i.e., steatosis graft) bears the risk of poor graft and patient survival. It is commonly recommended to use marginal and steatotic grafts in recipients who are in a relatively good clinical condition (i.e., MELD scores < 20) and avoid using them for fulminant or end-stage liver failure. In the presented case of a young female with acute liver failure, the use of a “high risk” graft (partial liver with approximately 40% macrovesicular steatosis) resulted in an excellent short and long term outcome. She survived immunosuppression weaning without any neurological sequelae after the auxiliary partial orthotopic liver transplantation.