Prospective Study
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 7, 2016; 22(5): 1902-1910
Published online Feb 7, 2016. doi: 10.3748/wjg.v22.i5.1902
Effectiveness and safety of continuous wound infiltration for postoperative pain management after open gastrectomy
Xing Zheng, Xu Feng, Xiu-Jun Cai
Xing Zheng, Department of Anesthesiology, Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou 310016, Zhejiang Province, China
Xu Feng, Xiu-Jun Cai, Department of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou 310016, Zhejiang Province, China
Author contributions: Zheng X designed the research and drafted the manuscript; Feng X collected data and performed statistical analysis; Cai XJ supervised the research and revised the manuscript.
Supported by Foundation of Health Department of Zhejiang Province, China, No. 2011RCA207; and Foundation of Education Department of Zhejiang Province, China, No. Y201431914.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board and Ethics Committee of Sir Run Run Shaw Hospital, Hangzhou, China.
Clinical trial registration statement: We applied for waiver of the clinical trial registration.
Informed consent statement: All study participants, or their legal guardian, provided written informed consent prior to study enrollment.
Conflict-of-interest statement: The authors declare that there is no conflict of interest related to this study.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Xiu-Jun Cai, PhD, Professor, Department of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, No. 3 Qingchun East Road, Hangzhou 310016, Zhejiang Province, China. cxjzu@hotmail.com
Telephone: +86-571-86090073 Fax: +86-571-86044817
Received: May 13, 2015
Peer-review started: May 19, 2015
First decision: September 29, 2015
Revised: October 28, 2015
Accepted: November 19, 2015
Article in press: November 19, 2015
Published online: February 7, 2016
Processing time: 252 Days and 16.7 Hours
Core Tip

Core tip: This prospective study compared the analgesic effectiveness and safety of continuous wound infiltration (CWI) with ropivacaine after open gastrectomy with epidural analgesia and patient-controlled intravenous analgesia. CWI could provide similar analgesia compared with epidural analgesia and patient-controlled intravenous analgesia within the first 48 h after surgery, but with lower morphine consumption, fewer side effects, and an accelerated early recovery. These results suggest that CWI with local anesthetics could be a suitable option for postoperative pain management after major abdominal surgery.