Basic Study
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 21, 2016; 22(47): 10364-10370
Published online Dec 21, 2016. doi: 10.3748/wjg.v22.i47.10364
ANGPTL2 expression in gastric cancer tissues and cells and its biological behavior
Wei-Zhong Sheng, Yu-Sheng Chen, Chuan-Tao Tu, Juan He, Bo Zhang, Wei-Dong Gao
Wei-Zhong Sheng, Yu-Sheng Chen, Bo Zhang, Wei-Dong Gao, Department of General Surgery, Fudan University Affiliated Zhongshan Hospital, Shanghai 200032, China
Chuan-Tao Tu, Juan He, Department of Digestion, Fudan University Affiliated Zhongshan Hospital, Shanghai 200032, China
Author contributions: Sheng WZ, Chen YS contributed equally to this work; Sheng WZ, Chen YS and Gao WD designed the research; Sheng WZ, Chen YS, Tu CT, He J, Zhang B and Gao WD performed the research; Chen YS, Tu CT, He J and Zhang B contributed new reagents/analytic tools; Sheng WZ and Chen YS analyzed the data; Sheng WZ and Gao WD wrote the paper.
Institutional review board statement: This study was reviewed and approved by the Fudan University Affiliated Zhongshan Hospital Institutional review board.
Conflict-of-interest statement: We declare that there are no conflicts of interest to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Wei-Dong Gao, MD, Associate Professor, Department of General Surgery, Fudan University Affiliated Zhongshan Hospital, No. 180 Fenglin Road, Shanghai 200032, China.
Telephone: +86-21-64041990 Fax: +86-21-64041990
Received: July 5, 2016
Peer-review started: July 8, 2016
First decision: August 8, 2016
Revised: August 25, 2016
Accepted: September 14, 2016
Article in press: September 14, 2016
Published online: December 21, 2016
Core Tip

Core tip: Expression of angiopoietin-like protein 2 (ANGPTL2) was significantly elevated in gastric cancer tissues and cells. The higher the level of malignancy of the cancer, the higher the expression of ANGPTL2 became. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and Transwell assays estimated that the proliferative and invasive ability of lentivirus-infected gastric cancer cells were evidently improved compared to the Lv-NC and blank control groups, which indicate that ANGPTL2 was conducive to the proliferation and invasion of gastric cancer cells.