Anti-viral role of toll like receptor 4 in hepatitis B virus infection: An in vitro study
Dipanwita Das, Neelakshi Sarkar, Ananya Pal, Debraj Saha, Manikankana Bandopadhyay, Runu Chakravarty, ICMR Virus Unit, Kolkata, ID and BG Hospital Campus, Kolkata 700010, India
Isha Sengupta, Chandrima Das, Biophysics and Structural Genomics Division, Saha Institute of Nuclear Physics, Kolkata 700064, India
Jimmy Narayan, Shivram Prasad Singh, Department of Gastroenterology, SCB Medical College, Cuttack 753007, India
Shivram Prasad Singh, Kalinga Gastroenterology Foundation, Beam Diagnostics Premises, Cuttack 753001, India
Author contributions: Das D, Sarkar N, Das C and Chakravarty R conceived and designed the experiments; Das D, Sarkar N, Sengupta I and Pal A performed the experiments; Das D, Sarkar N, Sengupta I, Das C, Narayan J, Singh SP and Chakravarty R analyzed the data; Das D, Sarkar N, Pal A, Saha D, Bandopadhyay M, Das C and Chakravarty R contributed reagents/materials/analysis tools; Das D, Sarkar N, Sengupta I, Pal A, Saha D, Bandopadhyay M, Das C and Chakravarty R wrote the paper.
Supported by the Indian Council of Medical Research (ICMR) intramural project; Das C acknowledges the financial support from Biomolecular Assembly, Recognition and Dynamics (BARD) project (Grant 12-R &D- SIN-5.04-0103) from Department of Atomic Energy (DAE), Government of India and Ramalingaswami Fellowship, Department of Biotechnology, Government of India.
Institutional review board statement: Signed informed consent was obtained from patients and the study was approved by the institutional ethical committee of Kalinga Gastroenterology Foundation.
Conflict-of-interest statement: The authors declare no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Runu Chakravarty, ICMR Virus Unit, Kolkata, ID and BG Hospital Campus, GB 4, Kolkata 700010, India. email@example.com
Telephone: +91-33-23537425 Fax: +91-33-23537424
Received: June 26, 2016
Peer-review started: June 27, 2016
First decision: August 29, 2016
Revised: October 1, 2016
Accepted: November 16, 2016
Article in press: November 16, 2016
Published online: December 21, 2016